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The Journal of Biological Chemistry logoLink to The Journal of Biological Chemistry
. 2019 Dec 27;294(52):20262. doi: 10.1074/jbc.W119.012036

Withdrawal: A novel interaction between the SH2 domain of signaling adaptor protein Nck-1 and the upstream regulator of the Rho family GTPase Rac1 engulfment and cell motility 1 (ELMO1) promotes Rac1 activation and cell motility.

Guo Zhang, Xia Chen, Fanghua Qiu, Fengxin Zhu, Wenjing Lei, Jing Nie
PMCID: PMC6937580  PMID: 31882523

VOLUME 289 (2014) PAGES 23112–23122

This article has been withdrawn at the request of the authors. The authors were recently made aware that the Coomassie Blue image in Fig. 1E was rotated 180°. The Myc immunoblot from lysate in Fig. 2B was reused in Figs. 2C and 6B. A portion of the GAPDH immunoblot in Fig. 2C was reused in Fig. 6B as GAPDH. The last lane of the Myc immunoblot from lysate in Fig. 3A was reused in the first lane of the Myc immunoblot from lysate in Fig. 3C. The first lane of the Myc immunoblot from lysate in Fig. 3E was reused in the last lane of the Myc immunoblot from lysate in Fig. 3G. The last lane of the Myc immunoblot from the IP in Fig. 3E was reused in the first lane of the Myc immunoblot from the IP in Fig. 4C. A portion of the Myc immunoblot from the lysate in Fig. 4A was reused as the HA immunoblot from lysate in Fig. 6C. A portion of the GAPDH immunoblot in Fig. 5A was reused in Fig. 6C as GAPDH. Although the authors believe that the biological conclusions outlined in the article are valid, the figures presented in the paper do not provide an accurate representation of the original data, and therefore the scientific integrity of the study has been compromised. The authors unanimously agree that the most appropriate course of action is to withdraw the article. All authors sincerely apologize to the scientific community for not detecting these errors prior to publication and any negative impact this may have caused.


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