Reverse Total Shoulder Arthroplasty: Biomechanics and Indications

Abstract

Purpose of Review

Over the past decade, our understanding of the biomechanics of the reverse total shoulder arthroplasty (RTSA) has advanced, resulting in design adjustments, improved outcomes, and expanding indications. The purpose of this review is to summarize recent literature regarding the biomechanics of RTSA and the evolving indications for its use.

Recent Findings

While Grammont’s principles of RTSA biomechanics remain pillars of contemporary designs, a number of modifications have been proposed and trialed in later generations to address complications such as impingement and glenoid failure. Clinical and biomechanical literature suggest that less medialized, more inferior glenospheres result in less impingement and notching. On the humerus, a more vertical neck cut is associated with less impingement. Indications for RTSA continue to expand beyond the classic indication of cuff tear arthropathy (CTA). Patients without a functional cuff but no arthritis now have a reliable option in the RTSA. RTSA has also replaced hemiarthroplasty as the implant of choice for displaced three- and four-part proximal humerus fractures in the elderly. Finally, updated design options and modular components now allow for treatment of glenoid bone loss, failed arthroplasty, and proximal humerus tumors with RTSA implants.

Summary

Reverse total shoulder arthroplasty design has been modernized on both the glenoid and humerus to address biomechanical challenges of early implants. As outcomes improve with these modifications, RTSA indications are growing to address complex bony pathologies such as tumor and bone loss. Longitudinal follow-up of patients with updated designs and novel indications is essential to judicious application of RTSA technology.

Introduction

Following its Food and Drug Administration (FDA) approval in 2003, reverse total shoulder arthroplasty (RTSA) has become increasingly popular in the USA. RTSAs comprised one-third of shoulder arthroplasties in the USA performed in 2011, and 46% in 2014 [1, 2]. The popularity of the RTSA stemmed initially from its success in pseudoparalytic shoulders secondary to cuff tear arthropathy (CTA), a condition for which the anatomic total shoulder arthroplasty (TSA) performed poorly [3, 4]. While initial reverse-polarity arthroplasties faced similar issues as the anatomic TSA, the introduction of the Grammont RTSA in 1985 provided a solution by re-tensioning the deltoid and medializing the center of rotation [3, 5].

The initial description of the basic biomechanics of the RTSA provided insight into how and why this prosthesis works, but since its introduction there has been an expanding body of literature on implications of this shoulder arthroplasty design [3, 6–10]. Updated understandings of the biomechanics and associated complications, such as scapular notching, have allowed for refinements in component positioning and implant design to improve range of motion (ROM), maintain the deltoid lever arm, and minimize joint reactive forces [8, 11–16]. The importance of understanding the biomechanics of reverse shoulder anatomy is crucial to produce optimal outcomes after RTSA. The indications for RTSA continue to expand from its FDA-approved use for CTA to indications ranging from massive rotator cuff tears, proximal humerus fractures, primary osteoarthritis, failed anatomic TSA, and orthopedic oncologic conditions. This review will focus on the basic biomechanics, contemporary updates to prosthesis design, and the expanding indications of RTSA.

Biomechanics

Prior to the development of the RTSA, addressing arthritis in cuff-deficient shoulders was challenging. Available implants failed to address the inherent instability of the shoulder girdle occurring with loss of dynamic compression from the rotator cuff [17, 18]. As a result, early prosthesis failure through superior humeral head migration and glenoid loosening from eccentric loading occurred frequently [5, 19].

The revolutionary Grammont reverse prosthesis was available in Europe in 1985, and was based on four key principles that altered the biomechanics of the prosthesis to mitigate shortcomings of its predecessors in the cuff-deficient shoulder [4]. These principles included (1) medialization of the center of rotation, (2) re-tensioning of the deltoid by distalizing the humerus, (3) a constant center of rotation leading to an inherently stable implant, and (4) a semi-constrained prosthesis with a larger arc of motion [3, 6]. These four principles have remained a staple in the understanding of RTSA biomechanics.

Medialized Center of Rotation

With the center of rotation (COR) medialized compared with an anatomic shoulder (Fig. 1a and b), but lateralized to or flush with the glenoid, the RTSA confers stability at the bone-implant interface. Movements around the fixed COR convert the compressive and shear forces into a largely compressive vector (Fig. 1b) [6, 9]. Forces across the shoulder joint are altered due to these altered biomechanics of the RTSA. In a native shoulder, at 90° of abduction there is a 90% body weight joint reactive force, and up to 42% body weight shearing force is seen at 60° abduction [20]. Peak forces are reduced in both compression and shear across the shoulder joint throughout ROM in reverse total shoulders [21, 22]. In one cadaveric study, Ackland and colleagues suggested that that glenohumeral joint force in abduction decreases by 41.5%BW [22]. In a shoulder lacking the compressive force of the cuff, minimization of the ratio of shear to compressive forces at the joint leads to an inherently stable prosthesis.

Fig. 1.

(a–d) Biomechanical improvements of the reverse total shoulder implants. a The natural center of rotation (COR) and deltoid lever arm (DL) in a native shoulder. (b) Starting with the Grammont implant, more modern reverse total shoulder arthroplasty implants medialize and distalize the center of rotation, which minimizes shear forces (FS), and increases compressive forces (FC), to create an overall favorable force vector (FV) at the bone-glenoid interface, as well as re-tensions the deltoid to provide a mechanical advantage. (c) In a native shoulder, the middle deltoid (red) and part of the anterior deltoid (light red) provide an abduction force. The posterior deltoid in dark red provides extension force. (d) With medialization of the center of rotation in a reverse total shoulder arthroplasty, a larger part of the anterior deltoid and posterior deltoid are recruited and contribute to the active abduction force. (Adapted from Berliner et al, JSES 2015 and Boileau et al, JSES 2005)

Re-tensioning of the Deltoid

With the deltoid as the primary workhorse for motion in the cuff-deficient shoulder, the RTSA design has maximized deltoid efficiency by COR medialization and deltoid lengthening. Several changes occur regarding the deltoid biomechanics in RTSA. The orientation of the muscle fibers becomes more vertical, and muscle recruitment changes such that all three sub-regions of the deltoid become primary shoulder abductors (Fig. 1c and d) [22, 23]. One cadaver study demonstrated increased moment arms of the anterior and middle deltoid by 10 and 15 mm respectively [23]. Other studies have noted a 20–42% increase in the deltoid moment arm, with a peak in the middle deltoid moment arm at 90° [9, 21], as well as improved deltoid abduction efficiency by 30% compared with native shoulders [21, 24]. Clinically, these changes have translated to improved range of motion in multiple studies [25, 26].

These changes in muscle recruitment for abduction are not without cost. As the posterior deltoid is recruited to become an abductor, its external rotation moment arm is lost, contributing to the common external rotation deficit seen following RTSA [16, 27]. Other directional moment arms are affected following RTSA as well, and, more recently, subscapularis repair after RTSA has been investigated. A sonographic study correlated the integrity of a subscapularis repair with post-operative PROs and determined that there was no significant difference between intact, attenuated, or absent subscapularis muscles, though internal rotation was improved in patients with intact tendons [28].

An Inherently Stable Shoulder

The minimization of shear forces conferred by a constant, medial COR leads to an inherently stable prosthesis. Furthermore, the radius of curvature in the glenoid and humeral components are congruent in an RTSA, allowing it to tolerate a greater joint reaction force vector up to 45° [6]. RTSA stability has been found to be two to three times higher than an anatomic TSA, and up to five times more stable than a native shoulder joint at 90° abduction [29]. Furthermore, likely due to the larger muscle forces acting throughout abduction, increasing angles of abduction confer greater forces required to dislocate the RTSA [30].

A Semi-constrained Prosthesis

A semi-constrained prosthesis is achieved by utilizing a relatively larger glenosphere relative to the humeral cup component. Early models consisted of a ball on socket design, similar to that of a total hip arthroplasty, but these highly constrained implants failed frequently due to elevated torque at the bone-implant interface leading to loosening. Furthermore, functional outcomes were poor due to low ROM prior to impingement. The Grammont RTSA offered a semi-constrained design, with a smaller humeral cup to provide larger ROM prior to impingement.

Modern RTSA implants have strove to balance the amount of constraint—with a humeral component deep enough to allow inherent stability in a cuff-deficient shoulder, but shallow enough to minimize impingement and shear forces generated in extremes of motion. More constraint increases the force required to dislocate the prosthesis, though this depends on the direction of force [30]. When compared with other variables possibly affecting ROM prior to impingement, the largest impact was shown to be humeral cup depth—a more retentive humeral cup reduced the ROM by 26° compared with the standard semi-constrained cup [31]. Furthermore, although highly constrained RTSA implants had elevated forces at the bone-implant interface, a more recent study demonstrated that less constrained implants also have increased contact stresses, particularly at the inferior edge of the humeral component [32]. These results provide support for a semi-constrained prosthesis, rather than one at the extremes.

Design Changes

Since the introduction of Grammont’s principles, there have been multiple proposed changes to the design and component placement of RTSAs with goals of improve ROM and outcomes while reducing impingement. These adjustments include glenoid baseplate placement modifications as well as humeral-sided design changes.

Glenoid Position

Medialization of the COR decreases shear forces across the glenoid component and creates compressive forces at the bone-implant interface. Medialization results in less glenoid baseplate motion [9, 33, 34] and lower force generation by the deltoid to initiate motion compared with lateralized components [35, 36]. However, medialization may lead to increased scapular notching and reduced shoulder ROM due to impingement [36–38]. Clinically, in a study of 146 consecutive RTSAs, patients with increased medialization had decreased external rotation, but improved pain scores. Those with increased glenoid lateralization had less radiographic notching [39]. Other biomechanical and clinical studies have also demonstrated improved ROM with glenoid lateralization [11, 40, 41•, 42]. Solutions to address these contrasting benefits have included improving glenoid baseplate fixation, moving from a highly constrained to a semi-constrained joint, and more inferior placement and inferior tilt of the glenosphere to avoid notching [6, 43].

The superior-to-inferior position and tilt of the glenosphere has also been studied with regard to reducing impingement. Initially, a computer-based model predicted less impingement in inferiorly placed and inferiorly tilted implants [8]. In a CT modeling study, inferior tilt of the glenosphere and inferior eccentric placement of the glenosphere both improved predicted ROM compared with a standard concentric glenosphere [40]. However, other studies have raised concerns about glenoid fixation with a tilted configuration [44, 45]. Currently, inferiorly tilted and eccentric designs are available to allow for inferior positioning of the glenosphere. While short-term results have been promising [13, 46, 47], long-term results with these modern implants are not yet available.

Humeral Component Design

Humeral component design and position have also been modified to diminish impingement and improve ROM since Grammont’s initial designs. The Delta prosthesis humeral component neck-shaft angle was in 155° of valgus, providing superior stability in a cuff-deficient shoulder. However, this non-anatomic, nearly-horizontal humeral component is more likely to impinge on the lateral pillar of the scapula. More contemporary designs offer a neck-shaft angle closer to normal anatomy, with options between 135 and 145°. Biomechanical studies have demonstrated reduced impingement and improved ROM [8, 48], findings further supported in clinical studies demonstrating reduced notching in patients receiving implants with a lower neck-shaft angle [49, 50].

Humerus preparation has also been modified since Grammont’s inlay prosthesis. Grammont’s initial stem was straight with a horizontal inlay-type humeral tray. A theoretical advantage of the inlay stem is increased bony contact between the proximal component and bone. However, the inlay design involves reaming more metaphyseal bone and preparation may risk greater tuberosity fracture [51]. Curved-stem designs with an onlay proximal interface have been utilized as well. The onlay design preserves proximal bone, and is generally has a more varus cut, preserving greater tuberosity bone and minimizing damage to the remaining rotator cuff. Furthermore, these prostheses may be convertible to or from hemiarthroplasty and anatomic TSA. Intrinsic to the more vertical inclination is increased humeral offset. Modular onlay humeral stems allow for the humeral tray to be rotated on the stem, with intraoperative adjustment to low/high offset configurations [52]. A 3D modeling study comparing Grammont inlay stems with short onlay stems of different inclinations demonstrated improved ROM in adduction, extension, and external rotation with onlay stems [51]. A clinical study comparing 2-year outcomes of the Grammont-style inlay stem with a short, curved onlay stem found that scapular fracture was more common for the onlay stems, but radiographic notching occurred less and external rotation improvement was greater for the onlay stems [53]. Currently, both stem types are available on the market, though discrepant design features between manufacturers makes comparative studies for this particular variable difficult.

Scapular Notching

Scapular notching has been found to be present radiographically in approximately two-thirds of RTSAs at 2-year follow-up [3, 10, 54, 55]. In a prospective study predictors of notching in RTSA patients, concentric or superior glenoid placement were shown to have the largest effect on the occurrence of notching. Notching was significantly correlated with less active abduction and flexion [56]. A retrospective review demonstrated superior placement and superior tilting of the glenoid to be associated with notching, and notching has been associated with less strength and reduced active elevation [54]. Despite these findings, two studies found no observed difference in PROs in patients with and without notching [10, 54]. Other studies, however, have demonstrated differences in clinical outcomes regarding PROs, strength, and ROM [57, 58]. In addition to ROM concerns, the longevity of the glenoid component is of primary concern. Biomechanical studies demonstrate that in scapulae with a notch, glenoid fixation is impaired, with increased micromotion of the glenosphere to shear loads [34]. However, the relationship to long-term glenoid longevity remains unclear [59–62].

Multiples studies have examined glenoid component position as it relates to post-operative notching [46, 55, 57]. Eccentric inferior glenoid placement may allow for increased abduction/adduction ROM [55]. Even in other planes of motion such as internal and external rotation, an inferiorly translated glenoid improves motion [11]. A randomized trial with 50 patients found that utilization of eccentric versus concentric glenoid components demonstrated no difference in functional scores, shoulder ROM, or notching incidence. However, inferior placement with > 3.5 mm of overhang was shown to prevent notching [46]. Another series of 40 patients with inferiorly placed glenoid components had no events of notching post-operatively at 2-year minimum follow-up [14].

Indications for RTSA

Cuff Tear Arthropathy

Cuff tear arthropathy remains the only FDA-approved indication for RTSA, and outcomes after the initial learning curve in the USA are promising. A study with 5-year follow-up of RTSA in CTA demonstrated improved ROM in abduction (34° pre-operatively to 71° post-operatively) and forward flexion (55° to 110°), as well as significantly improved Constant scores at this time point [63]. The 10-year implant survival rate for CTA patients has been reported as 95% [64]. A systematic review of RTSA in CTA and massive cuff tears, however, showed a high complication rate across the studies of 17.4%, while ROM was significantly improved in all directions [65]. Aside from survivorship and functional outcomes, several reports have examined the impact of other factors, including pre-operative deltoid size and patient sex, on post-operative outcomes. Pre-operative deltoid size correlated with improved ASES scores and women overall had more pain post-operatively and inferior functional scores compared with men [66, 67].

Massive Irreparable Cuff Tears

Given its biomechanical advantage in a rotator cuff-deficient shoulder, RTSA is often used to address massive irreparable cuff tears in the absence of arthritis (Fig. 2). In a series of 112 patients with massive cuff tears, Cuff et al. reported 94% survivorship at 5 years and 90% at 10 years. Improved motion and functional scores were maintained at 10 years [68, 69]. Other studies demonstrated improvement in abduction and forward flexion by over 70° in each direction at mid-term follow-up [70]. Longer follow-up results, however, have been mixed. A longitudinal study with 15-year follow-up suggested a failure rate of 27% and almost a 60% complication rate, although constant scores and anterior elevation were improved overall at final follow-up. Constant scores for those who had complications (excluding those requiring revisions) were comparable with those without complications [71]. A systematic review showed no significant decrease in functional scores or ROM up to 20 years post-surgery [72]. Overall, a younger age at the time of surgery, prior rotator cuff repair, and higher pre-operative shoulder scores were associated with poorer outcomes in this population [73, 74].

Fig. 2.

(a, b) Massive rotator cuff tear with anterosuperior escape treated with reverse total shoulder arthroplasty. (a) A weighted abducted AP view demonstrates anterosuperior escape of the humeral head, indicating a lack of functional rotator cuff. (b) Post-operative radiograph demonstrating cemented reverse total shoulder arthroplasty

Proximal Humerus Fractures

One condition for which RTSA is becoming increasingly utilized is proximal humerus fractures (PHF) (Fig. 3). From 2011 to 2013, the rates of RTSA in management of PHF increased 1.8-fold, comprising 3 to 24% of surgical management of PHF [75]. One of the challenges with either primary fixation or hemiarthroplasty for PHF is achieving tuberosity healing, which is associated with improved outcomes. Again, given the altered biomechanics of the RTSA, this implant offers the possibility of improved function regardless of tuberosity healing. The use of RTSA surpassed the use of hemiarthroplasties by 2015, representing 67.4% of arthroplasty implants used for PHF in one registry report [76]. A prospective study of RTSA in comminuted PHF resulted in 97% of patients with stable fixation, average forward flexion of 130° and average external rotation of 32° [77]. A multicenter review of 52 shoulders, mean age of 77 with 35-month follow-up, demonstrated final absolute and relative constant scores of 62 and 86, with 92% of patients rating their outcome as excellent or good. Resected or displaced greater tuberosities on imaging did correlate with inferior clinical outcomes in this cohort [78]. Ross et al. demonstrated excellent results in a retrospective review of 29 shoulders with 4.5 year average follow-up—no revisions, an average constant score of 88, and an average American Shoulder and Elbow Surgeon Score of 89 in this population with three and four-part PHF [79].

Fig. 3.

(a–c) Reverse total shoulder arthroplasty for a proximal humerus fracture. (a, b) Anterior-posterior (a) and lateral (b) radiograph of the right shoulder demonstrates a displaced four-part proximal humerus fracture. (c) Following reverse total shoulder arthroplasty with a cemented stem with suture fixation of the greater and lesser tuberosities around the humeral component

Comparisons of RTSA with hemiarthroplasty for treatment of PHF has generally favored RTSA in terms of improved functional motion, pain scores, and revision rate. A matched case-control prospective study in three- and four-part PHF demonstrated a higher proportion of subjects with forward elevation > 90° in the RTSA cohort, although there were no detectable differences in function scores between the two groups [80]. In a randomized trial of 62 patients over the age of 70 with PHF comparing hemiarthroplasty with RTSA, the RTSA group had higher UCLA and constant scores, and superior ROM in abduction and forward elevation. The healing status of the tuberosities did not affect the functional outcomes of the RTSA group, and more hemiarthroplasties required revision [81]. A meta-analysis confirmed superior outcomes regarding ROM, pain, and functional scores in RTSA compared with hemiarthroplasty [82].

Despite promising data on outcomes of this population when managed with RTSA, comparison between RTSA and non-operative management of PHF does not consistently demonstrate that superiority of RTSA. A 5-year review of 218 RTSA and 427 hemiarthroplasties showed no difference between functional outcomes or revision rate [83]. In a retrospective review of 39 patients with three- or four-part PHF managed with either RTSA or non-operatively, there was no difference in forward elevation, external rotation, or PROs at 2 years [84]. Chivot et al. reviewed 60 patients aged 70 or older with three- or four-part PHF, and although the RTSA cohort demonstrated higher constant scores than the non-operative cohort, there was no difference in other functional scores. Anterior elevation was improved in the RTSA group compared with the non-operative group (110° versus 98°); however, there were more complications in the RTSA group (7% versus 0%) [85]. Furthermore, delayed primary RTSA compared with acute primary RTSA yielded similar clinical results and reoperation rates, suggesting that perhaps in this frail population a trial of non-operative management may be prudent when appropriate [86].

Glenoid Bone Loss

Due to the potential fixation strength of the glenoid component in RTSA, RTSA may be considered for patients with severe glenoid bone loss, such as from primary osteoarthritis, tumor, inflammatory arthritis, or failed prior arthroplasty [87]. Glenoid bone loss resulting in a biconcave (B2) or severely retroverted and dysplastic (C) glenoid may be considerations for RTSA based on other patient characteristics (Fig. 4). For instance, Walch reported glenoid loosening in anatomic shoulder arthroplasties with biconcave glenoids that was present in over 20% of patients and the revision rate was 16.3% at average 77-months follow-up [88].

Fig. 4.

(a–e) Reverse total shoulder arthroplasty with an augmented glenoid component. Grashey (a) and axillary lateral (b) radiographs demonstrate glenohumeral arthritis with superior migration of the humeral head. (c) CT scan axial cuts demonstrate a dysplastic Walch C type glenoid. AP (d) and axillary lateral (e) radiographs following reverse total shoulder arthroplasty. The glenoid baseplate consists of a porous metal backed lateralizing augment, marked with a yellow arrow. Note the restoration of glenoid version with the posteriorly augmented component

Bone grafting of the glenoid to achieve sufficient bony fixation, to restore the glenoid version with posterior augmentation, and to lateralize the COR to avoid impingement on the coracoid and scapula is also a possible option [89–91]. Mizuno et al. reported results from a retrospective series of 27 patients with primary osteoarthritis of the shoulder with a biconcave glenoid treated with RTSA from 1998 to 2009 [92]. In this series, average retroversion was 32°; 10 patients received posterior bone grafting. There were significant improvements in PROs and ROM with complications in 15% of patients and no recurrent posterior instability at minimum 2-year follow-up. Gupta et al. described outcomes following bone grafting during RTSA in one of the largest contemporary series of 94 patients [93•]. A single-stage procedure was feasible in 92.5% of patients, and the authors recommended considering a two-stage procedure when intraoperative glenoid baseplate stability was unsatisfactory. Bone grafting was recommended if medialization occurred past the point of the coracoid.

Some companies have marketed implants or techniques specifically to address glenoid bone loss. The bony increased offset-reversed shoulder arthroplasty (BIO-RSA) is an option in which cancellous humeral head autograft is used to lateralize the COR, and in medium-term follow-up, has demonstrated excellent graft incorporation, a low rate of scapular notching, and satisfactory post-operative ROM [89]. Novel implant designs (Fig. 4) may allow for correction of retroversion or bone loss with a wedge or stepped implant. At this time there is no graft technique or implant which has comparative data demonstrating clear superiority. Future clinical studies will better define the appropriate indications for these implants and patient outcomes after implantation.

Revision Shoulder Arthroplasty

Reverse total shoulder arthroplasty may also be indicated for use in the setting of failed anatomic or hemiarthroplasty. If the rotator cuff fails in the setting of a hemiarthroplasty or anatomic TSA, instability and anterosuperior escape may manifest [94]. The reverse prosthesis is a reasonable solution as it does not rely on the rotator cuff for stability. In a study of 22 patients with failed total shoulder arthroplasty, conversion to RTSA resulted in improved subjective and functional outcomes though with higher complication rate than primary RTSA [95]. Relatedly, if there is nonunion, malunion, or resorption of the tuberosities following HA for PHF, RTSA can be used as a salvage operation [96].

Another indication for revision may be glenoid wear in hemiarthroplasty, or glenoid component failure in anatomic or reverse TSA [97]. In these settings, glenoid bone stock may not be adequately addressed by a revision anatomic TSA, even if the rotator cuff is intact. Due to the ability of the RTSA prosthesis to make up for deficient rotator cuff (which is necessary for both hemiarthroplasty and anatomic TSA) and provide glenoid resurfacing with less glenoid bone stock due to enhanced fixation options, it is becoming a more common solution to challenging revision arthroplasty cases.

Tumor

Reverse total shoulder arthroplasty is also a viable option in the setting of oncologic resection (Fig. 5) [98]. These patients may be younger and require substantial resection depending on the tumor size. If a wide oncologic resection necessitates removal of the tuberosities, then RTSA may be the only implant that allows for restoration of joint stability and preservation of shoulder function. In a study of 8 patients who underwent reversed proximal humeral endoprosthesis following tumor resection, Maclean et al. showed 100% revision-free survival at mean follow-up of 49 months with no local recurrence [99]. Forward flexion and abduction were less than 90° on average, but pain control was satisfactory. In a study of 13 patients with proximal humerus tumors necessitating resection, a two-surgeon approach with an orthopedic oncologist and a shoulder-trained surgeon yielded acceptable clinical results and no complications [100]. The authors recommended long-stemmed, modular components, optimization of stability through component positioning and soft tissue tensioning, and consideration for patients with a life expectancy of greater than 6 months.

Fig. 5.

(a–d) Reverse total shoulder reconstruction with endoprosthesis for tumor. (a) AP radiograph of the right shoulder demonstrates a lytic lesion in the right humeral head and metaphysis with pathologic fracture from metastatic hepatocellular carcinoma. (b) T2-weighted axial MRI image demonstrates a T2-bright heterogenous lesion replacing the bone of the humeral head. (c and d) Post-operative AP (c) and axillary lateral (d) radiographs of the right shoulder and humerus following proximal humerus resection and reconstruction with long-stemmed, cemented reversed polarity implant, which was performed with a shoulder arthroplasty-trained surgeon and an orthopaedic oncology surgeon

Conclusions

The reverse shoulder replacement has revolutionized the treatment of many challenging and complex shoulder pathologies. Through alterations to the native shoulder biomechanics, the RTSA provides a stable shoulder in the absence of a functioning rotator cuff. While only FDA-approved for patients with cuff tear arthropathy, emerging clinical evidence shows the efficacy of this treatment for a variety of clinical conditions. Future clinical studies will help clarify the role of further advances in implant design and surgical technique to optimize outcomes.

Compliance with Ethical Standards

Conflict of Interest

Caitlin M. Rugg, Monica J. Coughlan and Drew. A. Lansdown declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.