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. 2019 Dec 10;24(24):4513. doi: 10.3390/molecules24244513

Figure 4.

Figure 4

TCDCA inhibited the activation of AP-1. (A) Inhibition of c-Jun, phosphorylated c-Jun (Ser63) and c-Fos are detected by immunoblotting using specific antibodies, β-actin was used as a loading control. Untreated FLS was used as a negative control, and Dex was used as a positive control. (B) RU486 blocked the suppression of phosphorylation of c-Jun (Ser63) and expression of c-Fos induced by TCDCA. (C) TCDCA inhibited AP-1 activity. Results were representative of three independent experiments. ** P < 0.01 vs. control, # P < 0.05, ## P < 0.01 vs. IL-1β.