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. 2020 Jan 2;7(1):ENEURO.0428-19.2019. doi: 10.1523/ENEURO.0428-19.2019

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Copyright © 2020 Dexter et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — Overexpression of P97 affects photoreceptor survival in Gγ₁^-/- mice. A–F, Morphology of Gγ₁^-/- retinas with or without P97 overexpression at three (A–C) or six (D–F) months of age. A, D, Spider diagrams representing the number of photoreceptor nuclei in 100-μm segments of the inferior and superior retina at various distances from the optic nerve head. The number of mice analyzed at three months of age was the following: WT, 3; Gγ₁^-/-, 7; Gγ₁^-/-/P97oe, 3. The number of mice analyzed at six months of age was the following: WT, 4; Gγ₁^-/-, 6; Gγ₁^-/-/P97oe, 4. B, E, The total number of nuclei in all eight 100-μm retinal segments represented in panels A, D. C, F, Representative images of inferior and superior retina cross-sections at the 1-mm distance from the optic nerve head. Scale bar = 25 μm. Data are shown as mean ± SD. n.s. indicates p > 0.05. **p < 0.01.