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. 2019 Nov 21;11(12):2855. doi: 10.3390/nu11122855

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Modulation by OC and OA of TNF-α-induced miRNA expression in adipocytes and in exosomes isolated from conditioned media. SGBS cells were pretreated with OC or OA 25 µmol/L (6 h) and then stimulated with 10 ng/mL TNF-α for 18 h. Total miRNAs were extracted from cells, and miR-34a-5p (A), miR-155-5p (B) and let-7c-5p levels (C) were measured by qPCR, analysed using the Ct method and normalized to SNORD6 levels. Total miRNAs were extracted from exosomes, and exo-miR-34a (D), exo-miR-155 (E) and exo-let-7c (F) levels were measured by qPCR, analyzed using the Ct method and normalized to Cel-miR-39. Bars represent means ± SD (n = 3). * p < 0.05 versus CTL. ** p < 0.01 versus CTL. *** p < 0.001 versus CTL. # p < 0.05 versus TNF-α. ### p < 0.001 versus TNF-α.