Table 2.

EC₅₀ values of the triple & quadruple modified CSP2 analogs against the ComD1 and ComD2 receptors^a

			ComD1		ComD2
Peptide Number	Peptide Name	Sequence	EC50 (nM)b	95% CIc	EC50 (nM)b	95% CIc
16	CSP2(15)-I4LL9RF13L	EMRLSRIIRDFLLLR	>1000	--	79.4	53.2–118
17	CSP2(15)-I4LL9RL14Q	EMRLSRIIRDFLFQR	166	110–249	19.3	11.2–33.1
18	CSP2(15)-I4LF13LL14Q	EMRLSRIILDFLLQR	874	663–1150	11.4	7.20–18.0
19	CSP2(15)-L9RF13LL14Q	EMRISRIIRDFLLQR	>1000	--	18.6	9.28–35.3
20	CSP2(15)-I4LL9RF13LL14Q	EMRLSRIIRDFLLQR	193	160–233	17.3	15.7–19.2

^aSee experimental section for detail of reporter strains. See supporting information for methods and plots of agonism dose response curves. All assays were performed in triplicates.

^bEC₅₀ values were determined by testing peptides over a range of concentrations.

^c95% confidence interval.