Table 5.

MiRNAs associated with metastasis in TNBC.

MiRNA	Direct/Indirect Targets	Functions	Reference
Oncogenic miRNAs
miR-182	PFN1, FOXF2	Promote cell proliferation, invasion, and migration	[115,116]
miR-373	TXNIP	Induces cancer cell EMT and metastasis	[117,118]
miR-10b	HOXD10	Promotes invasion and metastasis	[119]
miR-21	PTEN	Lymph node metastasis	[120]
miR-17/92 cluster	COL4A3, LAMA3, TIMP2/3	Lymph node metastases, promote metastasis	[121,122]
miR-629-3p	LIFR	Lung metastases	[123]
miR-455-3p	EI24	Promotes proliferation, invasion, and migration	[124]
miR-125b	APC	Promotes proliferation, metastasis, and EMT	[125]
miR-181a	Bim	Promotes EMT, migratory, and invasive	[72]
Oncosuppressor miRNAs
miR-200a/b/c	PKCα, UBASH3B, XIAP	Suppress proliferation, migration, invasion, and metastasis, promote apoptosis	[77,126,127]
miR-205	Unknown	Lymph node metastasis	[128]
let-7	RAS, c-Myc	Block growth and reduce metastasis	[129]
miR-145	MUC1, Arf6, JAM-A, Fascin	Reduce cell motility, invasiveness, and metastasis	[130,131,132]
miR-206	CORO1C	Regulates metastasis	[133]
miR-30a	ROR1	Associates with high histological grade and more lymph node metastasis	[134]
miR-190a/940	Unknown	Prevents metastasis and cell invasion	[19,135]
miR-33b	HMGA2, SALL4, Twist1	Inhibit metastasis	[114]
miR-146a-5p	SOX5	Inhibits proliferation and metastasis	[136]
miR-150	HMGA2	Inhibits metastasis	[137]
miR-124	ZEB2	Inhibits invasion and metastasis	[138]
miR-148a	WNT1, NRP1	Suppress metastasis	[139]
miR-126-3p	RGS3	Inhibits proliferation, migration, invasion, and angiogenesis	[140]
miR-508-3p	ZEB1	Inhibits cell invasion and EMT	[141]
miR-613	Daam1	Inhibits cell migration and invasion	[142]
miR-519d-3p	LIMK1	Suppresses growth and motility	[143]
miR-26a	MTDH	Suppresses proliferation and metastasis	[144]
miR-130a	FOSL1, ZO-1	Suppress migration and invasion	[145]