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. 2019 Nov 22;8(12):1492. doi: 10.3390/cells8121492

Table 6.

MiRNAs associated with proliferation in TNBC.

miRNA Direct/Indirect Targets Functions Reference
Oncogenic miRNAs
miR-182 PFN1 Promotes TNBC cell proliferation [115]
miR-21 PTEN Promotes TNBC cell proliferation [90]
miR-206 RASA1, SPRED1 Promote TNBC cell proliferation [47]
miR-146a/146b-5p BRCA1 Increases BRCA1-mediated proliferation [146]
miR-498 BRCA1 Promotes TNBC cell proliferation [147]
miR-25-3p BTG2 Promotes TNBC cell proliferation [148]
miR-20a-5p RUNX3, Bim, p21 Promote TNBC cell proliferation [149]
miR-135b APC Promotes proliferation and metastasis [150]
miR-502 STE8 Promotes cell proliferation and cell cycle [25]
Oncosuppressor miRNAs
miR-203 BIRC5, LASP1 Suppress cell proliferation and migration [151]
miR-205 ErbB3, VEGF-A, E2F1, LAMC1 Inhibit cell proliferation, cell invasion, cell cycle arrest, clonogenic potential [152,153]
miR-200c XIAP Inhibits proliferation, induces apoptosis [126]
miR-34a Notch-1, ErbB2, c-SRC Inhibit cell growth and invasion, activate senescence, sensitize to dasatinib [154,155,156]
miR-940 ZNF24 Inhibits cell proliferation and migration [157]
miR-211-5p SETBP1 Inhibits cell proliferation and migration [158]
miR-1301 EZH2 Suppresses proliferation, migration, and colony formation [159]
miR-146a-5p SOX5 Inhibits the proliferation and metastasis [136]
miR-26a MTDH Suppresses tumor proliferation and metastasis [144]
miR-490-3p TNKS2 Inhibits the growth and invasiveness [160]
miR-143-3p LIMK1 Suppresses the growth [161]
miR-17-5p ETV1 Suppresses cell proliferation and invasion [162]
miR-539 LAMA4 Inhibits proliferation and migration [163]
miR-125b MAP2K7 Inhibits proliferation [164]
miR-217 KLF5 Inhibits cell growth, migration [165]
miR-589 MTA2 Decreases cell proliferation, migration, and invasion [166]