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. 2019 Nov 27;8(12):1524. doi: 10.3390/cells8121524

Figure 4.

Figure 4

Scatter plots showing cell index values of endothelial cells measured by the xCELLigence system in the context of extracellular vesicles (EV) administration (a), LL-cbMSC (b) and bmMSC (c) EV effect on pro-angiogenic bFGF and PDGF-AA growth factors (GFs), LL-cbMSC (d) and bmMSC (e) EV effect on angiogenic inhibitor angiostatin (AS). (f) Schematic of EV-shuttled NG2 mechanisms of action on bFGF and PDGF-AA signaling and on angiostatin inhibitory effect to support endothelial cell growth. Statistical analysis was by Kruskal–Wallis non-parametric one-way ANOVA followed by Dunn’s multiple comparisons test; * p < 0.05, ** p < 0.01, *** p < 0.001, all vs. CTR condition; °° p < 0.05, °°° p < 0.05, all vs. GFs or AS conditions; §§§ p < 0.05 vs. EV condition. a.u., arbitrary units; CTR, untreated endothelial cells; αNG2, NG2 antibody.