Table 3.
Name | Eligibility | N | Intervention | Duration | Endpoint | Outcome | |
---|---|---|---|---|---|---|---|
FINGER Lance 2015t | FINnish GERriatric Intervention Study to Prevent Cognitive Impairment and Disability | 60–70 years old Cardiovascular Risk Factors Aging and Dementia score (CAIDE) ≥ 6 points |
1260 46% Female |
Diet, exercise, cognitive training, vascular risk monitoring versus control | 2 years | Neuropsychological test battery (NTB) Z score |
NTB score higher in Intervention P = 0.030 |
MAPT Lancet Neurology 2017 |
Multidomain Alzheimer Prevention Trial |
70+ years old 1) Memory complaints 2) Limitations in ADL or 3) Slow gait |
1525 65% Female |
4 arms, Multidomain (MD) +placebo; Omega 3 FA alone; MD + Omega 3 FA; placebo |
3 years | Composite Z score Combining 4 cognitive tests |
No significant effect on cognitive decline compared to placebo |
NU-AGE Diet Frontier in Physiology 2018 |
New dietary strategies addressing the specific needs of the elderly population for healthy ageing in Europe | 67–79 years old Free of dementia relatively healthy older adults |
1279 100% Female |
NU-AGE DIET, Medi, like versus usual diet control |
1 year | Cognitive function Mini-Mental State Examination (MMSE) Plus CERAD score |
No overall difference Higher adheres Improvement in global function |
PREDIMED-NAVARRA J Neurol Neurosurg Psychiatry 2013 |
Prevención con Dieta Mediterránea | Age 75 years (mean) High vascular risk |
522 55% Female |
3 arms, 2 MedDiets ± extra-virgin olive oil or mixed nuts versus “low fat” control** |
6.5 years | Mini-Mental State Examination (MMSE) plus Clock Drawing Test (CDT) |
MedDiets higher than control MMSE, P = 0.005 CDT, P = 0.001 |