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. 2019 Nov 28;267(1):257–258. doi: 10.1007/s00415-019-09648-8

Correction to: Longitudinal multi-modal muscle-based biomarker assessment in motor neuron disease

Thomas M Jenkins 1,2,, James J P Alix 1,3, Jacob Fingret 1, Taniya Esmail 1, Nigel Hoggard 4, Kathleen Baster 5, Christopher J McDermott 1,2, Iain D Wilkinson 4, Pamela J Shaw 1,2
PMCID: PMC6954882  PMID: 31781929

Correction to: Journal of Neurology 10.1007/s00415-019-09580-x

The original version of this article unfortunately contained a mistake. The numbers in the Table 5 appear to have been reproduced wrongly as dates, rather than percentages.

The corrected Table 5 is given in the next page.

Table 5.

Longitudinal radiological changes in relative T2-signal in MND patients

Muscle Mean % change in relative T2-signal between baseline and 4 months (95% CI) P value Mean % change in relative T2-signal between baseline and 12 months (95% CI) P value SRM Var ratio
Tongue − 4.8 (− 11.2, 1.5) 0.123 − 2.4 (− 10.2, 5.4) 0.540 − 0.08 0.66
Right trapezius − 6.9 (− 19.1, 5.2) 0.251 0.2 (− 14.5, 14.8) 0.981 0.06 0.17
Left trapezius − 10.9 (− 22.9, 0.9) 0.066 − 1.7 (− 16.1, 12.8) 0.816 − 0.02 0.17
Right sternocleidomastoid − 3.7 (− 13.4, 6.0) 0.443 0.3 (− 11.5, 12.2) 0.949 0.10 0.43
Left sternocleidomastoid − 4.4 (− 14.5, 5.6) 0.376 − 4.1 (− 16.3, 8.2) 0.502 − 0.11 0.37
Splenius capitis 4.2 (− 4.3, 12.8) 0.321 − 5.4 (− 16.0, 5.1) 0.297 − 0.42 0.47
Right deltoid 2.7 (− 5.0, 10.4) 0.486 − 4.8 (− 14.4, 4.7) 0.304 − 0.27 0.71
Left deltoid 1.9 (− 6.6, 10.4) 0.654 4.6 (− 5.8, 15.2) 0.365 0.08 0.59
Right biceps brachii − 2.2 (− 13.8, 9.4) 0.700 11.3 (− 2.9, 25.7) 0.107 0.18 0.55
Left biceps brachii − 3.5 (− 17.4, 10.1) 0.597 − 1.9 (− 18.6, 14.7) 0.814 − 0.21 0.26
Right triceps − 13.9 (− 47.2, 18.0) 0.378 − 22.3 (− 65.1, 18.4) 0.266 − 0.19 0.10
Left triceps − 0.0 (− 31.3, 31.2) 0.998 − 0.0 (− 22.1, 22.1) 0.708 − 0.18 0.00
Right brachioradialis 7.3 (− 15.0, 29.9) 0.507 10.4 (− 15.4, 36.8) 0.414 0.04 0.06
Left brachioradialis 7.0 (− 16.8, 31.2) 0.551 9.9 (− 19.3, 39.6) 0.492 0.82 0.23
Right first dorsal interosseous 18.4 (− 1.8, 39.8) 0.067 31.1 (6.8, 57.4) 0.010 0.64 0.43
Left first dorsal interosseous − 0.0 (− 26.2, 24.6) 0.952 16.1 (− 16.2, 50.4) 0.311 0.97 0.41
Right thenar 14.4 (− 7.1, 36.6) 0.177 21.4 (− 4.9, 48.9) 0.100 0.76 0.26
Left thenar − 8.7 (− 42.1, 23.8) 0.586 − 10.0 (− 50.1, 29.8) 0.607 − 0.57 0.17
Right hypothenar 5.5 (− 10.6, 22.0) 0.491 13.8 (− 5.8, 34.4) 0.155 0.27 0.73
Left hypothenar 3.1 (− 12.6, 18.8) 0.691 2.3 (− 16.2, 20.9) 0.802 0.22 0.34
Right thoracic paraspinal − 1.0 (− 4.4, 2.4) 0.903 16.7 (− 3.0, 37.6) 0.087 0.30 0.69
Left thoracic paraspinal 1.6 (− 12.1, 15.5) 0.811 4.2 (− 12.7, 21.4) 0.610 0.24 0.70
Right psoas 6.2 (− 19.9, 33.1) 0.627 35.7 (4.6, 71.1) 0.020 0.53 0.52
Left psoas − 11.8 (− 42.8, 17.9) 0.419 − 15.7 (− 54.1, 20.9) 0.382 − 0.01 0.31
Right gluteus maximus − 3.0 (− 24.3, 18.1) 0.774 22.0 (− 3.1, 48.8) 0.076 0.44 0.49
Left gluteus maximus − 14.2 (− 42.3, 12.2) 0.277 − 14.8 (− 49.8, 18.4) 0.363 − 0.10 0.53
Right quadriceps 5.4 (− 2.5, 13.6) 0.168 18.8 (9.0, 29.6) < 0.001* 0.86 0.90
Left quadriceps 1.2 (− 7.4, 9.7) 0.784 11.4 (2.9, 20.6) 0.028 0.39 0.91
Right hamstrings − 2.2 (− 10.2, 5.6) 0.564 17.4 (7.7, 28.2) < 0.001* 0.98 0.93
Left hamstrings 1.9 (− 7.1, 11.0) 0.666 14.4 (3.3, 26.3) 0.008* 0.65 0.89
Right tibialis anterior 10.7 (0.8, 21.2) 0.030 28.5 (15.9, 42.7) < 0.001* 0.82 0.87
Left tibialis anterior 4.1 (− 7.9, 16.5) 0.180 20.9 (6.0, 37.2) 0.004* 0.33 0.86
Right gastrocnemius/soleus 5.6 (− 3.2, 14.7) 0.200 18.9 (8.0, 30.6) < 0.001* 0.64 0.83
Left gastrocnemius/soleus 0.5 (− 8.2, 9.1) 0.911 18.7 (8.0, 30.3) < 0.001* 0.78 0.88
Muscle-of-onset − 0.08 (− 16.1, 16.0) 0.698 16.6 (− 2.9, 37.3) 0.070 0.77 0.73
Region-of-onset 2.7 (− 4.3, 9.7) 0.437 14.1 (5.5, 23.2) 0.001* 0.87 0.89
Summary mean − 0.1 (− 6.2, 5.9) 0.972 8.8 (1.3, 16.4) 0.017 0.36 0.56

Significant T2-weighted radiological changes in MND patients between baseline and subsequent 4 and 12 month time-points are highlighted in bold. Results surviving multiple comparisons correction are asterisked

CI confidence interval, SRM standardized response mean, Var variance


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