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Dissolution of caffeine over time for four immediate release dosage forms in the paddle apparatus. The stirring speed was 75 rpm, the medium temperature was 37 ± 0.5 °C and a total volume of 900 mL simulated gastric fluid pH 1.2 without pepsin was used. The drug concentrations were determined by fiber optic UV measurement at 272 nm (mean ± SD, n = 6).
