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. 2019 Nov 3;9(1):1684126. doi: 10.1080/2162402X.2019.1684126

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — ISG product levels predict CR after ILP.

The serum concentration of (a) CXCL10, (b) CCL2, (c) PD-L2 and (d) IFN-γ in melanoma patients achieving a complete response (CR) and not achieving a complete response (Non-CR) before (pre-op.) and 1 month after (post-op.) ILP (non-paired Mann-Whitney test). The serum concentration of (e) CXCL10, (f) CCL2, (g) PD-L2 and (h) IFN-γ in melanoma patients and in healthy controls (Ctrl) (paired Wilcoxon test between pre-op. and post-op., non-paired Kruskal-Wallis test followed by Dunn’s multiple comparison test for ctrl vs. pre-op. and vs. post-op). Data are presented in box-and-whiskers plots with min. and max. (i,j) Patients were dichotomized by above or below median levels of CXCL10, CCL2, PD-L2 and IFN-γ and were grouped based on having above median levels of 0–1 ISG products, or 2–4 ISG products. The fraction of patients within each group achieving CR or not (non-CR) are shown for ISG-grouping based on (i) pre-op. samples (n = 38) and (j) post-op. samples (n = 11; Fisher’s exact test).