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. 2020 Feb;26(2):162–174. doi: 10.1261/rna.072264.119

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© 2020 Xiao and MacRae; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 3. — Mathematical model for Ago2–miRNA time-course distribution of two competing targets. (A) Illustration of Ago2–miRNA binding two competing target RNAs. (B) Predicted fractions of target-1 (blue) and target-2 (red) bound by Ago2–miR122-v1 plotted as a function of time (solid lines). Experimental data from Figure 2 are included for comparison (open circles and squares). Dashed line indicates region shown in panel C. (C) Close up view of earliest time point in panel B. Solid lines indicate predicted fractions of target RNAs bound by Ago2–miR122-v1.