Figure 2.

DHRS2 expression is upregulated by HDAC inhibitors. A. Upregulated genes shown in clusters based on the collection of gene signatures for HDACi (http://scads.jfcr.or.jp/db/cs/ushi2012.html), including TSA and SAHA. B. DHRS2 alterations common in tumors cell and OC tissues, obtained from the cBioPortal. C and D. qRT-PCR and western blot showing DHRS2 expression in ES2 cells (C) and A2780 cells (D) after treatment with SAHA, apicidin and TSA for 48 h. *data were obtained using a different probeset_id.