Fig. 6.

Inhibition of AMPKα1 is synergistic with oxaliplatin. a Cell apoptosis in HCT116 and RKO cells expressing control-shRNA (sh-NC), sh-2 RNA, or sh-3 RNA after oxaliplatin treatment. Representative images and quantification are shown. b Intracellular ROS levels in HCT116 and RKO cells were detected with DCF-DA. c Cell survival of SW1116 and DLD1 cells treated by oxaliplatin (60 μM) was measured by CCK-8 assay. d Tumor volumes after tail vein administration of different formulas until day 26. e The images of HCT116 tumor tissue after indicated treatments. f Tumor volumes after tail vein administration of different formulas until day 18 in a PDX model. *P < 0.05, **P < 0.01, Student’s t-test