Table 2.

Proteomic studies on single species A. actinomycetemcomitans.

Author	Year (Ref)	Brief Description	Identified Proteins *	Proteomic Application, Label Free Quantification	Cutoff	PMID
Llama-Palacios et al.	2017 [171]	A.a planktonic and mono-species biofilm cultures	50	2DE, MALDI-TOF MS	N/A	28707473
Kieselbach T et al.	2016 [155]	A.a outer membrane vesicles dataset	501	In solution digestion, LC-MS/MS	protein FDR < 1%	28050585
Kieselbach T et al.	2015 [154]	A.a outer membrane vesicles	151	In solution digestion, LC-MS/MS	protein FDR < 1%	26381655
Smith KP et al.	2015 [175]	A.a membrane proteins related to morphogenesis protein C	613	Stable-isotope dimethyl labeling, nanoscale LC-MS	FP < 1%	25684173
Smith KP et al.	2015 [176]	A.a membrane proteins	648	Stable-isotope dimethyl labeling, nanoscale LC-MS	FP < 1%	25055881
Zijnge V et al.	2012 [177]	A.a secreted proteins from mono-species biofilm	179	2DE, HCT-Ultra ETD II IT-MS	Peptide ion score > 30	22848560
Rylev M et al.	2011 [178]	A.a JP2 strain HK1651	114	2DE, MALDI-TOF MS	N/A	21867783

Ion trap: IT, False positive: FP, False-discovery rate: FDR, Matrix assisted laser desorption ionization: MALDI, Time of flight mass spectrometry: TOF MS, Mass spectrometer: MS. * Maximum identified/quantified proteins were report base on the following rules: (1) Only maximum identified protein number was reported if the experiment was done under different conditions. (2) Total protein numbers were reported if the experiment has replicates. (3) The number of identified and quantified proteins were reported if only regulated protein were reported.