Table 3.

Baseline Physical Function and Comorbidities in 10 CT Imaging Subtypes

Characteristic	No. of Subjects						Moderate to Severe Centrilobular Emphysema
		No CT Imaging Abnormality	Paraseptal Emphysema	Bronchial Disease	Small Airway Disease	Mild Emphysema	Upper Lung Predominant	Lower Lung Predominant	Diffuse	Discordant Visual	Discordant Quantitative	P Valuea
No. of subjects		2,339	2,018	861	381	1,755	309	53	706	527	131	…
Oxygen saturation at rest, %	9,095	96.9 ± 2.1	95.8 ± 3.2	96.4 ± 2.6	96.5 ± 2.4	96.3 ± 2.5	94.0 ± 4.2	93.9 ± 4.2	94.0 ± 4.2	95.8 ± 3.0	96.5 ± 2.1	< .001
6-Minute walking distance, feet	8,974	1,487.2 ± 359.3	1,288.3 ± 395.3	1,331.3 ± 392.5	1,407.5 ± 359.3	1,423.5 ± 377.3	1,111.7 ± 395.6	1,063.0 ± 341.7	1,151.0 ± 407.2	1,251.9 ± 378.8	1,550.8 ± 394.6	< .001
SGRQ total score	9,097	17.8 ± 18.5	33.1 ± 23.6	30.5 ± 23.3	21.9 ± 20.3	23.1 ± 21.5	43.2 ± 20.9	46.8 ± 18.1	41.6 ± 20.4	31.2 ± 23.0	17.8 ± 19.6	< .001
Frequency of acute exacerbations of COPD per year	9,098	0.2 ± 0.6	0.5 ± 1.0	0.4 ± 1.0	0.3 ± 0.8	0.3 ± 0.9	0.8 ± 1.2	1.2 ± 1.6	0.7 ± 1.2	0.5 ± 1.1	0.3 ± 0.8	< .001

Data are mean ± SD. SGRQ = St. George’s Respiratory Questionnaire.

^aP value tests for differences across all 10 groups.