Table 1.
EEV courses of infection in macaque cohort.
| Virus | Macaque | Sex | Dose * | TTD δ | Neuro £ | ΔMax γ | Onset γ | Duration γ | Fever-Hours γ |
|---|---|---|---|---|---|---|---|---|---|
| EEEV | M161-16 | M | 8.2 | 6 | Y | 4.2 | 3 | 70.8 | 144.2 |
| M163-16 | M | 7.5 | 6 | Y | 4.4 | 3 | 65.0 | 154.9 | |
| Mean | 8.0 | 4.3 | 3 | 67.9 | 149.6 | ||||
| M160-16 | M | 7.0 | S | N | 0.7 | 14.3 | 6.5 | ||
| M162-16 | M | 5.7 | S | N | 1.8 | 41.5 | 30.5 | ||
| Mean | 6.8 | 1.3 | 27.9 | 18.5 | |||||
| VEEV | M164-16 | F | 7.1 | S | Y | 2.8 | 1 | 187.8 | 171.6 |
| M165-16 | F | 6.9 | S | Y | 3.1 | 1 | 260.5 | 282.5 | |
| M170-16 | M | 6.3 | S | Y | 2.9 | 1 | 180.5 | 153.8 | |
| M171-16 | M | 6.0 | S | Y | 3.3 | 1 | 238.0 | 305.9 | |
| Mean | 6.8 | 3.0 | 1 | 216.7 | 228.4 |
Macaques received aerosols of either EEEV or VEEV. * Doses in log10 pfu. £ Neuro = neurological signs (tremors, seizures, photophobia, head pressing), δ TTD = Time to death, S = Survived to 28 days post infection. γ Fever data. Δ Max = maximum difference from predicted; Onset = onset of fever duration > 8 h; Duration = fever duration, in hours; Fever-hours = summation of all significant differences in temperature from predicted. Additional clinical data (e.g., macaque age, weights, plaque reduction neutralizing titer) are in Supplemental Table S1.