Abstract
Objectives: Our objective was to estimate the burden of mortality attributable to long-term exposure to ambient fine particulate matter (PM2.5) among adults in two rural regions of British Columbia, the Interior and the North, in order to provide information for public health professionals setting health priorities.
Methods: We used the standard method to calculate the fraction of all-cause mortality among adults (≥30 years old) attributable to long-term exposure to ambient PM2.5 as described in the World Health Organization global burden of disease study. PM2.5 concentration was either locally measured using tapered element oscillating microbalance (TEOM) continuous monitors or estimated for unmonitored cities. For the base case, we used a conservative PM2.5 threshold (5.0 ug/m3); for sensitivity analysis, we set the threshold to estimate all mortality attributable to anthropogenic PM2.5 (3.1 ug/m3). We conducted sensitivity analysis for PM2.5 concentrations estimated in unmonitored cities.
Results and Conclusions: Mean annual PM2.5 concentration ranged from 3.1 to 7.4 ug/m3 across local health areas in Northern and Interior BC. Sixty percent of the adult population lived in monitored regions. PM2.5 was estimated to cause 0.20% of all-cause mortality among adults (16 deaths/year). Anthropogenic PM2.5 was estimated to cause 0.93% of all-cause mortality among adults (74 deaths/year). Estimates were sensitive to both PM2.5 threshold and estimated PM2.5 in unmonitored communities. This demonstrates that ambient PM2.5 air pollution does have an important mortality burden, even in a region with relatively low PM2.5 concentrations.
Keywords: Air pollution, particulate matter, public health, British Columbia, Canada, mortality
Résumé
Objectifs: Estimer le fardeau de la mortalité attribuable à l’exposition à long terme aux particules fines dans l’air ambiant (PM2,5) chez les adultes de deux régions de la Colombie-Britannique, l’Intérieur et le Nord, afin de donner de l’information aux professionnels de santé publique qui établissent les priorités de santé.
Méthode: Nous avons utilisé la méthode standard pour calculer la fraction de la mortalité toutes causes confondues chez les adultes (≥30 ans) attribuable à l’exposition à long terme aux PM2,5 dans l’air ambiant comme décrite dans l’étude de l’Organisation mondiale de la Santé sur la charge mondiale de morbidité. La concentration en PM2,5 a été soit mesurée localement à l’aide d’échantillonneurs en continu à microbalance à oscillation, soit estimée (pour les villes sans relevé local). Pour le scénario de base, nous avons utilisé un seuil modeste de PM2,5 (5,0 µg/m3); pour l’analyse de sensibilité, nous avons fixé le seuil de manière à estimer la mortalité toutes causes confondues attribuable aux PM2,5 d’origine anthropique (3,1 µg/m3). Nous avons réalisé des analyses de sensibilité pour les concentrations estimatives en PM2,5 dans les villes sans relevé local.
Résultats et conclusions: La concentration annuelle moyenne en PM2,5 s’échelonnait de 3,1 à 7,4 µg/m3 dans les régions sanitaires locales du Nord et de l’Intérieur de la C.-B. Soixante pour cent de la population adulte vivait dans des régions avec relevé local. Nous estimons que les PM2,5 et les PM d’origine anthropique ont causé respectivement 0,20 % et 0,93 % de la mortalité toutes causes confondues chez les adultes (respectivement 16 et 74 décès/an). Les estimations étaient sensibles à la fois au seuil des PM2,5 et au seuil estimatif dans les communautés sans relevé local. Cela démontre que la pollution de l’air ambiant par les PM2,5 contribue à la charge de mortalité, même dans les régions à concentration relativement faible en PM2,5.
Motsclés: pollution de l’air, particules; santé publique, Colombie-Britannique, Canada, mortalité
Footnotes
Conflict of Interest: None to declare.
References
- 1.Bell ML, Davis DL. Reassessment of the lethal London fog of 1952: Novel indicators of acute and chronic consequences of acute exposure to air pollution. Environ Health Perspect. 2001;109(Suppl3):389–94. doi: 10.1289/ehp.01109s3389. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Pope CA, III, Muhlestein JB, May HT, Renlund DG, Anderson JL, Horne BD. Ischemic heart disease events triggered by short-term exposure to fine par-ticulate air pollution. Circulation. 2006;114(23):2443–48. doi: 10.1161/CIRCULATIONAHA.106.636977. [DOI] [PubMed] [Google Scholar]
- 3.Kwon HJ, Cho SH, Chun Y, Lagarde F, Pershagen G. Effects of the Asian dust events on daily mortality in Seoul, Korea. Environ Res. 2002;90(1):1–5. doi: 10.1006/enrs.2002.4377. [DOI] [PubMed] [Google Scholar]
- 4.Committee on the Medical Effects of Air Pollutants. Cardiovascular disease and air pollution. A report by the Committee on the Medical Effects of Air Pollutants. London, UK: Department of Health; 2006. [Google Scholar]
- 5.Klemm RJ, Mason R. Replication of reanalysis of Harvard Six-City mortality study. Revised analyses of time-series studies of air pollution and health, Part II. Boston, MA: Health Effects Institute; 2003. pp. 165–72. [Google Scholar]
- 6.Dominici F, Daniels M, McDermott A, Zeger SL, Samet J. Shape of the exposure-response relation and mortality displacement in the NMAPS database. Revised analyses of time-series studies of air pollution and health, Part II. Boston: Health Effects Institute; 2003. pp. 91–96. [Google Scholar]
- 7.Katsouyanni K, Touloumi G, Samolu E, Petasakis Y, Analitis A, Le Tertre A, et al. Sensitivity analysis of various models of short-term effects of ambient particles on total mortality in 29 cities in APHEA2. Revised analyses of time-series studies of air pollution and health, Part II. Boston: Health Effects Institute; 2003. pp. 157–64. [Google Scholar]
- 8.Ostro B, Broadwin R, Green S, Feng WY, Lipsett M. Fine particulate air pollution and mortality in nine California counties: Results from CALFINE. Environ Health Perspect. 2006;114(1):29–33. doi: 10.1289/ehp.8335. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 9.Dockery D, Pope C, Xu X, Spengler J, Ware J, Fay M, et al. An association between air pollution and mortality in six U.S. cities. N Engl J Med. 1993;329:1753–59. doi: 10.1056/NEJM199312093292401. [DOI] [PubMed] [Google Scholar]
- 10.Krewski D, Burnett RT, Goldberg MS, Hoover K, Siemiatycki J, Jarret M, et al. Reanalysis of the Harvard Six Cities Study and the American Cancer Society Study of Particulate Air Pollution and Mortality. Boston: Health Effects Institute; 2000. [Google Scholar]
- 11.Laden F, Schwartz J, Speizer F, Dockery D. Reduction in fine particulate air pollution and mortality: Extended follow-up of the Harvard Six Cities study. Am J Respir Crit Care Med. 2006;173:667–72. doi: 10.1164/rccm.200503-443OC. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 12.Pope C, Thun M, Namboodiri M, Dockery D, Evans J, Speizer F, et al. Partic-ulate air pollution as a predictor of mortality in a prospective study of US adults. Am J Respir Crit Care Med. 1995;151:669–74. doi: 10.1164/ajrccm/151.3_Pt_1.669. [DOI] [PubMed] [Google Scholar]
- 13.Pope C, Burnett R, Thun M, Calle E, Krewski D, Ito K, et al. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA. 2002;287:1132–41. doi: 10.1001/jama.287.9.1132. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 14.Pope C, Burnett R, Thurston G, Thun M, Calle E, Krewski D, et al. Cardiovascular mortality and long-term exposure to particulate air pollution: Epi-demiological evidence of general pathophysiological pathways of disease. Circulation. 2004;109:71–77. doi: 10.1161/01.CIR.0000108927.80044.7F. [DOI] [PubMed] [Google Scholar]
- 15.Pope CA, III, Ezzati M, Dockery DW. Fine-particulate air pollution and life expectancy in the United States. N Engl J Med. 2009;360(4):376–86. doi: 10.1056/NEJMsa0805646. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16.Stieb DM, Burnett RT, Smith-Doiron M, Brion O, Shin HH, Economou V. A new multipollutant, no-threshold air quality health index based on short-term associations observed in daily time-series analyses. J Air Waste Manag Assoc. 2008;58(3):435–50. doi: 10.3155/1047-3289.58.3.435. [DOI] [PubMed] [Google Scholar]
- 17.British Columbia Provincial Health Officer. Every breath you take. Provincial Health Officer’s annual report, 2003. Air quality in British Columbia, a public health perspective. Victoria, BC: Ministry of Health Services; 2004. [Google Scholar]
- 18.British Columbia Vital Statistics Agency. Regional population estimates and projections. Victoria, BC: Ministry of Health Services; 2009. [Google Scholar]
- 19.Pope C, Dockery D. Health effects of fine particulate air pollution: Lines that connect. J Air Waste Manage. 2006;56(6):709–42. doi: 10.1080/10473289.2006.10464485. [DOI] [PubMed] [Google Scholar]
- 20.Steenland K, Armstrong B. An overview of methods for calculating the burden of disease due to specific risk factors. Epidemiol. 2006;17(5):512–19. doi: 10.1097/01.ede.0000229155.05644.43. [DOI] [PubMed] [Google Scholar]
- 21.Greenland S. Variance estimators for attributable fraction estimates consistent in both large strata and sparse data. Stat Med. 1987;6(6):701–8. doi: 10.1002/sim.4780060607. [DOI] [PubMed] [Google Scholar]
- 22.Cohen A R, Anderson H, Ostro B, Pandey KD, Krzyzanowski M, Künzli N, et al. Chapter 17. Urban air pollution. In: Ezzati M, Lopez AD, Rodgers A, Murray CJL, et al., editors. Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attribution to Selected Major Risk Factors, Volume 2, Part 2: Environmental and occupational risk factors. Copenhagen, Denmark: World Health Organization Regional Office for Europe; 2004. pp. 1353–433. [Google Scholar]
- 23.Smith KR, Peel JL. Mind the gap. Environ Health Perspect. 2010;118(12):1643–45. doi: 10.1289/ehp.1002517. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 24.Oberg M, Jaakkola MS, Woodward A, Peruga A, Pruss-Ustun A. Worldwide burden of disease from exposure to second-hand smoke: A retrospective analysis of data from 192 countries. Lancet. 2011;377(9760):139–46. doi: 10.1016/S0140-6736(10)61388-8. [DOI] [PubMed] [Google Scholar]
- 25.British Columbia Vital Statistics Agency. Appendix 3: Selected health status indicators by local health area, health service delivery area and health authority. British Columbia, 2005–2009. Selected vital statistics and health status indicators (One hundred thirty-eighth annual report) Victoria: Ministry of Health Services; 2009. [Google Scholar]
- 26.Krzyzanowski M, Cohen A. Quantification of the health effects of exposure to air pollution. Report of a WHO Working Group. Bilthoven, Netherlands: World Health Organisation European Centre for Environment and Health; 2001. [Google Scholar]
- 27.McDonnell WF, Nishino-Ishikawa NAOMI, Petersen FF, Chen LH, Abbey DE. J Expo Anal Environ Epidemiol. 2000. Relationships of mortality with the fine and coarse fractions of long-term ambient PM10 concentrations in nonsmokers. [DOI] [PubMed] [Google Scholar]
- 28.Lipfert F, Baty J, Miller J, Wyzga R. PM2.5 constituents and related air quality variables as predictors of survival in a cohort of U.S. military veterans. Inhal Toxicol. 2006;18(9):645–57. doi: 10.1080/08958370600742946. [DOI] [PubMed] [Google Scholar]
