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Canadian Journal of Public Health = Revue Canadienne de Santé Publique logoLink to Canadian Journal of Public Health = Revue Canadienne de Santé Publique
. 2011 Sep 1;102(5):324–327. doi: 10.1007/BF03404169

Lower Risk Cannabis Use Guidelines for Canada (LRCUG): A Narrative Review of Evidence and Recommendations

Benedikt Fischer 12,22,, Victoria Jeffries 12, Wayne Hall 32, Robin Room 42,62, Elliot Goldner 12, Jürgen Rehm 22,52
PMCID: PMC6973752  PMID: 22032094

Abstract

Objectives: More than one in ten adults–and about one in three young adults–report past year cannabis use in Canada. While cannabis use is associated with a variety of health risks, current policy prohibits all use, rather than adopting a public health approach focusing on interventions to address specific risks and harms as do policies for alcohol. The objective of this paper was to develop ‘Lower Risk Cannabis Use Guidelines’ (LRCUG) based on research evidence on the adverse health effects of cannabis and factors that appear to modify the risk of these harms.

Methods: Relevant English-language peer-reviewed publications on health harms of cannabis use were reviewed and LRCUG were drafted by the authors on the basis of a consensus process.

Synthesis: The review suggested that health harms related to cannabis use increase with intensity of use although the risk curve is not well characterized. These harms are associated with a number of potentially modifiable factors related to: frequency of use; early onset of use; driving after using cannabis; methods and practices of use and substance potency; and characteristics of specific populations. LRCUG recommending ways to reduce risks related to cannabis use on an individual and population level–analogous to ‘Low Risk Drinking Guidelines’ for alcohol–are presented.

Conclusions: Given the prevalence and age distribution of cannabis use in Canada, a public health approach to cannabis use is overdue. LRCUG constitute a potentially valuable tool in facilitating a reduction of health harms from cannabis use on a population level.

Keywords: Canada, cannabis, epidemiology, morbidity, policy, public health

Footnotes

Acknowledgements: The authors acknowledge research funding support from the Canadian Institute of Health Research (CIHR), the Michael Smith Foundation for Health Research (MSFHR), and the Ontario Ministry of Health and Long-Term Care for salary support for CAMH-affiliated authors. Wayne Hall is funded by an NHMRC Australia Fellowship.

Conflict of Interest: None to declare.

References

  • 1.Health Canada. Canadian Alcohol and Drug Use Monitoring Survey. 2010. [Google Scholar]
  • 2.Room R, Fischer B, Hall W, Lenton S R P. Cannabis Policy: Moving Beyond Stalemate. New York, NY: Oxford University Press and The Beckley Foundation; 2010. [Google Scholar]
  • 3.Dauvergne M. Trends in police-reported drug offences in Canada. Juristat. 2009;29:1–25. [Google Scholar]
  • 4.Room R, Babor T, Rehm J. Alcohol and public health: A review. Lancet. 2005;365:519–30. doi: 10.1016/S0140-6736(05)70276-2. [DOI] [PubMed] [Google Scholar]
  • 5.Fischer B, Rehm J, Irving H, Ialomiteanu A, Fallu J-S, Patra J. Typologies of cannabis users and associated characteristics relevant for public health: A latent class analysis of data from a nationally representative Canadian adult survey. Int J Methods Psychiatric Res. 2010;19:110–24. doi: 10.1002/mpr.307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.Angus Reid Strategies. Canadians want federal government to retain drug harm reduction programs. 2008. [Google Scholar]
  • 7.Bondy SJ, Rehm J, Ashley MJ, Walsh G, Single E, Room R. Low-risk drinking guidelines: The scientific evidence. Can J Public Health. 1999;90:264–70. doi: 10.1007/BF03404129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Lynskey MT, Coffey C, Degenhardt L, Carlin JB, Patton G. A longitudinal study of the effects of adolescent cannabis use on high school completion. Addiction. 2003;98:685–92. doi: 10.1046/j.1360-0443.2003.00356.x. [DOI] [PubMed] [Google Scholar]
  • 9.Fergusson DM, Boden JM. Cannabis use and later life outcomes. Addiction. 2008;103:969–76. doi: 10.1111/j.1360-0443.2008.02221.x. [DOI] [PubMed] [Google Scholar]
  • 10.Hall W, Degenhardt L. Adverse health effects of non-medical cannabis use. Lancet. 2009;374:1383–91. doi: 10.1016/S0140-6736(09)61037-0. [DOI] [PubMed] [Google Scholar]
  • 11.Anthony J. The epidemiology of cannabis dependence. In: Roffman R, Stephens R, editors. Cannabis Dependence: Its Nature, Consequences and Treatment. Cambridge, UK: Cambridge University Press; 2006. [Google Scholar]
  • 12.Kalant H. Adverse effects of cannabis on health: An update of the literature since 1996. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2004;28:849–63. doi: 10.1016/j.pnpbp.2004.05.027. [DOI] [PubMed] [Google Scholar]
  • 13.Fergusson DM, Horwood LJ, Ridder EM. Tests of causal linkages between cannabis use and psychotic symptoms. Addiction. 2005;100:354–66. doi: 10.1111/j.1360-0443.2005.01001.x. [DOI] [PubMed] [Google Scholar]
  • 14.Rey JM, Sawyer MG, Raphael B, Patton GC, Lynskey MT. Mental health of teenagers who use cannabis: Results of an Australian survey. Br J Psychiatry. 2002;180:216–21. doi: 10.1192/bjp.180.3.216. [DOI] [PubMed] [Google Scholar]
  • 15.McLaren JA, Silins E, Hutchinson D, Mattick RP, Hall W. Assessing evidence for a causal link between cannabis and psychosis: A review of cohort studies. Int J Drug Policy. 2010;21:10–19. doi: 10.1016/j.drugpo.2009.09.001. [DOI] [PubMed] [Google Scholar]
  • 16.Caspi A, Moffitt TE, Cannon M, McClay J, Murray R, Harrington H, et al. Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene X environment interaction. Biol Psychiatry. 2005;57:1117–27. doi: 10.1016/j.biopsych.2005.01.026. [DOI] [PubMed] [Google Scholar]
  • 17.Hall WD, Lynskey M. Is cannabis a gateway drug? Testing hypotheses about the relationship between cannabis use and the use of other illicit drugs. Drug Alcohol Rev. 2005;24:39–48. doi: 10.1080/09595230500126698. [DOI] [PubMed] [Google Scholar]
  • 18.Patton GC, Coffey C, Lynskey MT, Reid S, Hemphill S, Carlin JB, et al. Trajectories of adolescent alcohol and cannabis use into young adulthood. Addiction. 2007;102:607–15. doi: 10.1111/j.1360-0443.2006.01728.x. [DOI] [PubMed] [Google Scholar]
  • 19.Kelly E, Darke S, Ross J. A review of drug use and driving: Epidemiology, impairment, risk factors and risk perceptions. Drug Alcohol Rev. 2004;23:319–44. doi: 10.1080/09595230412331289482. [DOI] [PubMed] [Google Scholar]
  • 20.Coffey C, Carlin JB, Degenhardt L, Lynskey M, Sanci L, Patton GC. Cannabis dependence in young adults: An Australian population study. Addiction. 2002;97:187–94. doi: 10.1046/j.1360-0443.2002.00029.x. [DOI] [PubMed] [Google Scholar]
  • 21.Block R O, Leary DS, Hichwa RD, Augustinack JC, Boles Ponto LL, Ghoneim MM, et al. Effects of frequent marijuana use on memory related regional cerebral blood flow. Pharmacology, Biochemistry & Behavior. 2002;72:237–50. doi: 10.1016/S0091-3057(01)00771-7. [DOI] [PubMed] [Google Scholar]
  • 22.Pope HG, Yurgelun-Todd D. The residual cognitive effects of heavy marijuana use in college students. JAMA. 1996;275:521–27. doi: 10.1001/jama.1996.03530310027028. [DOI] [PubMed] [Google Scholar]
  • 23.Stefanis NC, Delespaul P, Henquet C, Bakoula C, Stefanis CN, van Os J. Early adolescent cannabis exposure and positive and negative dimensions of psychosis. Addiction. 2004;99:1333–41. doi: 10.1111/j.1360-0443.2004.00806.x. [DOI] [PubMed] [Google Scholar]
  • 24.Andreasson S, Allebeck P, Rydberg U. Schizophrenia in users and nonusers of cannabis. A longitudinal study in Stockholm County. Acta Psychiatr Scand. 1989;79:505–10. doi: 10.1111/j.1600-0447.1989.tb10296.x. [DOI] [PubMed] [Google Scholar]
  • 25.Fergusson DM, Horwood LJ, Swain-Campbell NR. Cannabis dependence and psychotic symptoms in young people. Psychol Med. 2003;33:15–21. doi: 10.1017/s0033291702006402. [DOI] [PubMed] [Google Scholar]
  • 26.Moore THM, Zammit S, Lingford-Hughes A, Barnes TRE, Jones PB, Burke M, et al. Cannabis use and risk of psychotic or affective mental health outcomes: A systematic review. Lancet. 2007;370:319–28. doi: 10.1016/S0140-6736(07)61162-3. [DOI] [PubMed] [Google Scholar]
  • 27.Fergusson DM, Horwood LJ. Early onset cannabis use and psychosocial adjustment in young adults. Addiction. 1997;92:279–96. doi: 10.1111/j.1360-0443.1997.tb03198.x. [DOI] [PubMed] [Google Scholar]
  • 28.Henquet C, Krabbendam L, de Graaf R, ten Have M, van Os J. Cannabis use and expression of mania in the general population. J Affect Disord. 2006;95:103–10. doi: 10.1016/j.jad.2006.05.002. [DOI] [PubMed] [Google Scholar]
  • 29.Andreasson S, Allebeck P. Cannabis and mortality among young men: A longitudinal study of Swedish conscripts. Scand J Soc Med. 1990;18:9–15. doi: 10.1177/140349489001800311. [DOI] [PubMed] [Google Scholar]
  • 30.Health Canada. Canadian Alcohol and Drug Use Monitoring Survey (CADUMS): Summary Results for 2008. Ottawa, ON: Health Canada; 2009. [Google Scholar]
  • 31.Tetrault JM, Crothers K, Moore BA, Mehra R, Concato J, Fiellin DA. Effects of marijuana smoking on pulmonary function and respiratory complications. Arch Intern Med. 2007;167:221–28. doi: 10.1001/archinte.167.3.221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 32.Hashibe M, Straif K, Tashkin DP, Morgenstern H, Greenland S, Zhang ZF. Epidemiologic review of marijuana use and cancer risk: A systematic review. Alcohol. 2005;35:265–75. doi: 10.1016/j.alcohol.2005.04.008. [DOI] [PubMed] [Google Scholar]
  • 33.Swift W, Copeland J, Lenton S. Cannabis and harm reduction. Drug Alcohol Rev. 2000;19:101–12. doi: 10.1080/09595230096200. [DOI] [Google Scholar]
  • 34.Tashkin DP. Effects of cannabis on the respiratory system. In: Kalant H, Corrigall W, Hall W, Smart R, editors. The Health Effects of Cannabis. Toronto, ON: Addiction Research Foundation; 1999. [Google Scholar]
  • 35.Hazekamp A, Ruhaak R, Zuurman L, van Gerven J, Verpoorte R. Evaluation of a vaporizing device (Volcano) for the pulmonary administration of tetra-hydrocannabinol. J Pharm Sci. 2006;95:1308–17. doi: 10.1002/jps.20574. [DOI] [PubMed] [Google Scholar]
  • 36.Gieringer D St, Laurent J, Goodrich S. Cannabis vaporizer combines efficient delivery of THC with effective suppression of pryolytic compounds. J Cannabis Therapeutics. 2004;4:7–27. doi: 10.1300/J175v04n01_02. [DOI] [Google Scholar]
  • 37.King LA, Carpentier C, Griffiths P. Cannabis potency in Europe. Addiction. 2005;100:884–86. doi: 10.1111/j.1360-0443.2005.001137.x. [DOI] [PubMed] [Google Scholar]
  • 38.Di Forti M, Morgan C, Dazzan P, Pariante C, Mondelli V, Marques TR, et al. High-potency cannabis and the risk of psychosis. Br J Psychiatry. 2009;195:488–91. doi: 10.1192/bjp.bp.109.064220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 39.Porath-Waller AJ, Beirness DJ, Beasley EE. Toward a more parsimonious approach to drug recognition expert evaluations. Traffic Inj Prev. 2009;10:513–18. doi: 10.1080/15389580903191617. [DOI] [PubMed] [Google Scholar]
  • 40.Ramaekers JG, Bergaus G, van Laar M, Drummer OH. Dose related risk of motor vehicle crashes after cannabis use. Drug Alcohol Depend. 2004;73:109–19. doi: 10.1016/j.drugalcdep.2003.10.008. [DOI] [PubMed] [Google Scholar]
  • 41.Fergusson DM, Horwood LJ, Boden JM. Is driving under the influence of cannabis becoming a greater risk to driver safety than drink driving? Findings from a longitudinal study. Accid Anal Prev. 2008;40:1345–50. doi: 10.1016/j.aap.2008.02.005. [DOI] [PubMed] [Google Scholar]
  • 42.Sewell RA, Poling J, Sofuoglu M. The effect of cannabis compared with alcohol on driving. Am J Addict. 2009;18:185–93. doi: 10.1080/10550490902786934. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 43.Grotenhermen F, Leson G, Berghaus G, Drummer OH, Kruger H, Longo M, et al. Developing limits for driving under cannabis. Addiction. 2007;102:1910–17. doi: 10.1111/j.1360-0443.2007.02009.x. [DOI] [PubMed] [Google Scholar]
  • 44.Ramaekers J, Berghaus G, van Laar M, Drummer O. Dose related risk of motor vehicle crashes after cannabis use. Drug Alcohol Depend. 2004;73:109–19. doi: 10.1016/j.drugalcdep.2003.10.008. [DOI] [PubMed] [Google Scholar]
  • 45.El Marroun H, Tiemeier H, Steegers EAP, Jaddoe VWV, Hofman A, Verhulst FC, et al. Intrauterine cannabis exposure affects fetal growth trajectories: The Generation R Study. J Am Acad Child Adolesc Psychiatry. 2009;48:1173–81. doi: 10.1097/CHI.0b013e3181bfa8ee. [DOI] [PubMed] [Google Scholar]
  • 46.Schempf AH. Illicit drug use and neonatal outcomes: A critical review. Obstet Gynecol Surv. 2007;62:749–57. doi: 10.1097/01.ogx.0000286562.31774.76. [DOI] [PubMed] [Google Scholar]
  • 47.Fergusson DM, Horwood LJ, Northstone K. ALSPAC Study Team. Maternal use of cannabis and pregnancy outcome. BJOG: Int J Obstetrics Gynaecol. 2002;109:21–27. doi: 10.1111/j.1471-0528.2002.01020.x. [DOI] [PubMed] [Google Scholar]
  • 48.Mittleman MA, Lewis RA, Maclure M, Sherwood JB, Muller JE. Triggering myocardial infarction by marijuana. Circulation. 2001;103:2805–9. doi: 10.1161/01.CIR.103.23.2805. [DOI] [PubMed] [Google Scholar]
  • 49.Degenhardt L, Hall W, Lynskey M. Testing hypotheses about the relationship between cannabis use and psychosis. Drug Alcohol Depend. 2003;71:37–48. doi: 10.1016/S0376-8716(03)00064-4. [DOI] [PubMed] [Google Scholar]
  • 50.van Os J, Bak M, Hanssen M, Bijl R, de Graaf R, Verdoux H. Cannabis use and psychosis: A longitudinal population-based study. Am J Epidemiol. 2002;156:319–27. doi: 10.1093/aje/kwf043. [DOI] [PubMed] [Google Scholar]

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