Skip to main content
Canadian Journal of Public Health = Revue Canadienne de Santé Publique logoLink to Canadian Journal of Public Health = Revue Canadienne de Santé Publique
editorial
. 2006 Nov 1;97(6):485–488. doi: 10.1007/BF03405233

Hepatitis C, Illicit Drug Use and Public Health

Does Canada Really Have a Viable Plan?

Benedikt Fischer 113,313,, Kate Kalousek 113,313, Jürgen Rehm 113,213, Jeff Powis 113,413, Mel Krajden 513,613, Jens Reimer 713
PMCID: PMC6975722  PMID: 17203734

Abstract

Some 300,000 individuals are infected with the hepatitis C virus (HCV) in Canada. HCV infection is associated with major morbidity, mortality and health care costs; these indicators are projected to rise over the next decade. The vast majority of prevalent and incident HCV infections in Canada are illicit drug use-related; thus, the HCV disease burden can only be addressed through interventions targeting this primary risk factor. Both preventive (e.g., needle exchange, methadone treatment) and therapeutic (e.g., the accessibility of HCV treatment for illicit drug users) interventions aimed at HCV in illicit drug users have been broadly expanded in Canada in recent years. However, evidence suggests that existing preventive measures only offer limited effectiveness in reducing HCV risk exposure. Also, due to restricted resources, treatment for HCV currently only reaches an extremely small proportion (i.e., <5%) of HCV-infected drug users. Thus, on the basis of current HCV incidence as well as given interventions and their impact, Canada is not achieving a net reduction in the prevalence of HCV-related to illicit drug use. In order to reduce the HCV disease burden, Canada needs to reconsider the scope, delivery and resourcing of both preventive and treatment interventions targeting the primary risk population of illicit drug users.

MeSH terms: Hepatitis C, public health, street drugs; policy, Canada

References

  • 1.Fischer B, Haydon E, Rehm J, Krajden M, Reimer J. Injection drug use and the hepatitis C virus: Considerations for a targeted treatment approach-The case study of Canada. J Urban Health. 2004;81:428–47. doi: 10.1093/jurban/jth128. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Buxton J. Vancouver Drug Use Epidemiology. 1–50. 2003. [Google Scholar]
  • 3.Fischer B, Rehm J, Brissette S, Brochu S, Bruneau J e-G N, et al. Illicit opioid users in Canada: Comparing social, health and drug use characteristics of untreated users in five cities (OPICAN study) J Urban Health. 2005;82:250–66. doi: 10.1093/jurban/jti049. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4.Roy E, Alary M, Morissette C. Épidémiologie de l’hépatite C chez les participants au réseau SurvUDI. 1–16. 2004. [Google Scholar]
  • 5.Zou S, Forrester L, Giulivi A. Hepatitis C update. Can J Public Health. 2003;94(2):127–29. doi: 10.1007/BF03404585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.Remis R. A study to characterize the epidemiology of hepatitis C infection in Canada, 2002. 2004. [Google Scholar]
  • 7.Sulkowski MS, Thomas DL. Epidemiology and natural history of hepatitis C virus infection in injection drug users: Implications for treatment. Clin Infect Dis. 2005;40(Suppl5):S263–S269. doi: 10.1086/427440. [DOI] [PubMed] [Google Scholar]
  • 8.Krahn M, Wong J, Heathcote J, Scully L, Seeff L. Estimating the prognosis of hepatitis C patients infected by transfusion in Canada between 1986 and 1990. Medical Decision Making. 2004;24:20–29. doi: 10.1177/0272989X03261568. [DOI] [PubMed] [Google Scholar]
  • 9.El Saadany S, Coyle D, Giulivi A, Afzal M. Economic burden of hepatitis C in Canada and the potential impact of prevention: Results from a disease model. Eur J Health Econ. 2005;6:159–65. doi: 10.1007/s10198-004-0273-y. [DOI] [PubMed] [Google Scholar]
  • 10.Health Canada. Hepatitis C as a roadmap for integrated communicable disease prevention and control: A strategy for the renewal of the Health Canada/Canadian Institutes of Health Research (CIHR) research initiative on hepatitis C. 20-1-2005. Ottawa, Joint Advisory Committee Health Canada/CIHR Research Initiative on Hepatitis C.
  • 11.Reimer J, Schulte B, Castells X, Schafer I, Polywka S, Hedrich D, et al. Guidelines for the treatment of hepatitis C virus infection in injection drug users: Status quo in the European Union countries. Clin Infect Dis. 2005;40(Suppl5):S373–S378. doi: 10.1086/427456. [DOI] [PubMed] [Google Scholar]
  • 12.Fischer B, Rehm J, Blitz-Miller T. Injection drug use and preventive measures: A comparison of Canadian and Western European jurisdictions over time. CMAJ. 2000;162:1709–13. [PMC free article] [PubMed] [Google Scholar]
  • 13.Wood E, Kerr T, Montaner JS, Strathdee SA, Wodak A, Hankins CA, et al. Rationale for evaluating North America’s first medically supervised safer-injecting facility. The Lancet Infect Dis. 2004;4:301–6. doi: 10.1016/S1473-3099(04)01006-0. [DOI] [PubMed] [Google Scholar]
  • 14.Backmund M, Reimer J, Meyer K, Gerlach JT, Reinhart Z. Hepatitis C virus infection and injection drug users: Prevention, risk factors, and treatment. Clin Infect Dis. 2005;40(Suppl5):S330–S335. doi: 10.1086/427475. [DOI] [PubMed] [Google Scholar]
  • 15.Sylvestre DL. Treating hepatitis C virus infection in active substance users. Clin Infect Dis. 2005;40(Suppl5):S321–S324. doi: 10.1086/427447. [DOI] [PubMed] [Google Scholar]
  • 16.Edlin BR, Kresina TF, Raymond DB, Carden MR, Gourevitch MN, Rich JD, et al. Overcoming barriers to prevention, care, and treatment of hepatitis C in illicit drug users. Clin Infect Dis. 2005;40(Suppl5):S276–S285. doi: 10.1086/427441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Pollack H, Heimer R, et al. The impact and cost-effectiveness of methadone maintenance treatment in preventing HIV and hepatitis C. In: Jager J, Limburg W, Kretzschmar M, et al., editors. EMCDDA Monographs: Hepatitis C and Injecting Drug Use: Impact, Costs and Policy Options. Luxembourg: EMCDDA; 2004. pp. 345–67. [Google Scholar]
  • 18.Pollack HA. Cost-effectiveness of harm reduction in preventing hepatitis C among injection drug users. Medical Decision Making. 2001;21:357–67. doi: 10.1177/0272989X0102100502. [DOI] [PubMed] [Google Scholar]
  • 19.Hagan H, McGough JP, Thiede H, Weiss NS, Hopkins SG, Alexander ER. Syringe exchange and risk of infection with hepatitis B and C viruses. Am J Epidemiol. 1999;149:203–13. doi: 10.1093/oxfordjournals.aje.a009792. [DOI] [PubMed] [Google Scholar]
  • 20.Garfein RS, Vlahov D, Galai N, Doherty MC, Nelson KE. Viral infections in short-term injection drug users: The prevalence of the hepatitis C, hepatitis B, human immunodeficiency, and human T-lymphotropic viruses. Am J Public Health. 1996;86:655–61. doi: 10.2105/AJPH.86.5.655. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21.Fischer B, Rehm J, Kim G, Robins A. Safer injection facilities (SIFs) for injection drug users (IDUs) in Canada: A review and call for an evidence-focused pilot trial. Can J Public Health. 2002;93(5):336–38. doi: 10.1007/BF03404564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 22.Mattick R, Kimber J, Kaldor J, MacDonald M, Weatherburn D, Lapsley H. Final Report of the Evaluation of the Sydney Medically Supervised Injecting Centre. 2003. [Google Scholar]
  • 23.Kerr T, Tyndall M, Li K, Montaner JSG, Wood E. The Lancet. 2005. Safer injection facility use and syringe sharing in injection drug users. [DOI] [PubMed] [Google Scholar]
  • 24.Haydon E, Fischer B. Crack use as a public health problem in Canada: Call for an evaluation of ‘safer crack use kits’. Can J Public Health. 2005;96(3):185–88. doi: 10.1007/BF03403687. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 25.Tortu S, McMahon J, Pouget E, Hamid R. Sharing of noninjection drug-use implements as a risk factor for hepatitis. Subst Use Misuse. 2004;39:211–24. doi: 10.1081/JA-120028488. [DOI] [PubMed] [Google Scholar]
  • 26.Fischer B, Rehm J, Kirst M, Casas M, Hall W, Krausz M, et al. Heroin-assisted treatment as a response to the public health problem of opiate dependence. Eur J Public Health. 2002;12:228–34. doi: 10.1093/eurpub/12.3.228. [DOI] [PubMed] [Google Scholar]
  • 27.Thiede H, Hagan H, Murrill C. Methadone treatment and HIV and hepatitis B and C risk reduction among injectors in the Seattle area. J Urban Health. 2000;77:331–45. doi: 10.1007/BF02386744. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 28.Hallinan R, Byrne A, Amin J, Dore GJ. Hepatitis C virus incidence among injecting drug users on opioid replacement therapy. Austr N Z J Public Health. 2004;28:576–78. doi: 10.1111/j.1467-842X.2004.tb00050.x. [DOI] [PubMed] [Google Scholar]
  • 29.Fischer B, Rehm J, Kim G, Kirst M. Eyes wide shut? A conceptual and empirical critique of methadone maintenance treatment. Eur Addict Res. 2005;11:1–12. doi: 10.1159/000081410. [DOI] [PubMed] [Google Scholar]
  • 30.Andonov A, Lin L, Wong G, Hill W, Boulos D, Tweed A, et al. Identification of Newly Acquired Hepatitis C Virus (HCV) Infection in British Columbia Based on Recent Seroconversion; Genotype Distribution for Years 2000–2003. 2004. [Google Scholar]
  • 31.Mangia A, Santoro R, Minerva N, Ricci GL, Carretta V, Persico M, et al. Peginterferon alfa-2b and ribavirin for 12 vs. 24 weeks in HCV genotype 2 or 3. N Engl J Med. 2005;352:2609–17. doi: 10.1056/NEJMoa042608. [DOI] [PubMed] [Google Scholar]
  • 32.Novick DM. The impact of hepatitis C virus infection on methadone maintenance treatment. The Mount Sinai J Med. 2000;67:437–43. [PubMed] [Google Scholar]
  • 33.Strathdee SA, Latka M, Campbell J, O’Driscoll PT, Golub ET, Kapadia F, et al. Factors associated with interest in initiating treatment for hepatitis C virus (HCV) infection among young HCV-infected injection drug users. Clin Infect Dis. 2005;40(Suppl5):S304–S312. doi: 10.1086/427445. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 34.Fischer B, Vasdev S, Haydon E, Rehm J, Baliunas D. Willingness for HCV treatment in a sample of Injecting Drug Users (IDUs) in Toronto, Canada. La Presse Médicale. 2005;34:1207–10. doi: 10.1016/S0755-4982(05)84158-2. [DOI] [PubMed] [Google Scholar]
  • 35.I-Track: Enhanced Surveillance of Risk Behaviours among Injecting Drug Users in Canada (Pilot Survey Report). 2004. Ottawa, Surveillance and Risk Assessment Division, Centre for Infectious Disease Prevention and Control, Population and Public Health Branch, Health Canada.
  • 36.Bell J, Dru A, Fischer B, Levit S, Sarfraz MA. Substitution therapy for heroin addiction. Subst Use Misuse. 2002;37:1149–78. doi: 10.1081/JA-120004176. [DOI] [PubMed] [Google Scholar]
  • 37.Kitahata MM, Van Rompaey SE, Dillingham PW, Koepsell T, Deyo R, Dodge W, et al. Primary care delivery is associated with greater physician experience and improved survival among persons with AIDS. J Gen Intern Med. 2003;18:95–103. doi: 10.1046/j.1525-1497.2003.11049.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 38.Backmund M, Meyer K, Edlin B. Infrequent reinfection after successful treatment for hepatitis C virus infection in injection drug users. Clin Infect Dis. 2004;39:1540–43. doi: 10.1086/425361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 39.Dalgard O. Follow-up studies of treatment for hepatitis C virus infection among injection drug users. Clin Infect Dis. 2005;40(Suppl5):S336–S338. doi: 10.1086/427449. [DOI] [PubMed] [Google Scholar]
  • 40.EMCDDA European Monitoring Centre for DrugsDrug Addiction. Annual Report: State of the Drugs Problem in the European Union and Norway. 2004. [Google Scholar]
  • 41.Dolan K, Clement N, Rouen D, Rees V, Shearer J, Wodak A. Can drug injectors be encouraged to adopt non-injecting routes of administration (NIROA) for drugs? Drug and Alcohol Rev. 2004;23:281–86. doi: 10.1080/09595230412331289437. [DOI] [PubMed] [Google Scholar]
  • 42.Hunt N, Griffiths P, Southwell M, Stillwell G, Strang J. Preventing and curtailing injecting drug use: A review of opportunities for developing and delivering ‘route transition interventions’. Drug and Alcohol Rev. 1999;18:441–51. doi: 10.1080/09595239996310. [DOI] [Google Scholar]
  • 43.Gonzalez G, Oliveto A, Kosten T. Combating opiate dependence: A comparison among the available pharmacological options. Expert Opinion on Pharmacotherapy. 2004;5:713–25. doi: 10.1517/14656566.5.4.713. [DOI] [PubMed] [Google Scholar]
  • 44.Mehta S, Cox A, Hoover D, Wang XH, Mao Q, Ray S, et al. Protection against persistence of hepatitis C. Lancet. 2002;359:1478–83. doi: 10.1016/S0140-6736(02)08435-0. [DOI] [PubMed] [Google Scholar]
  • 45.Hoofnagle J. Therapy for acute hepatitis C. N Engl J Med. 2001;345:1495–97. doi: 10.1056/NEJM200111153452013. [DOI] [PubMed] [Google Scholar]
  • 46.Thimme R, Oldach D, Chang K, Steiger C, Ray S, Chisari F. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Experimental Med. 2001;194:1395–406. doi: 10.1084/jem.194.10.1395. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Canadian Journal of Public Health = Revue Canadienne de Santé Publique are provided here courtesy of Springer

RESOURCES