Flupirtine given after the 1st electroclinical seizure reduces (A) the percent of rats with electroclinical seizures and (B) the number and (C) total duration of electroclinical seizures during the remaining hypoxia period. The data shown in the B and C histograms are mean ± SD. *p < 0.05, ***p < 0.0005, Student’s two-tailed t-test. ECS = electroclinical seizure, HI = hypoxia-ischemia, V = vehicle, F = flupirtine.