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Centriolar satellites are substrates of selective autophagy. The centriolar satellite (CS) protein PCM1 directly binds GABARAP/L2 through a LIR motif. This interaction mediates the selective engulfment of the CSs targeted for degradation into phagphores. Notably, autophagy inhibition results in loss of pericentriolar material integrity, which has an impact on centrosome stability and causes aberrant mitoses.
