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Schematic of CA7-4 regulating VEC autophagy and apoptosis caused by high glucose. High glucose induces VEC autophagy and apoptosis. In this progress, upregulated CA7-4 as a miRNA sponge to decoy MIR877-3P and MIR5680, promote the expression of CTNNBIP1 and DPP4, decrease the level of CTNNB1 and increase AMPK phosphorylation. 3BDO can attenuate high glucose-induced VEC autophagy and apoptosis by weakening the upregulation of CA7-4.
