Fig. 2.

Schematic of the androgen receptor. Schematic representation of the androgen receptor (AR), depicting key functional domains of the protein. Shown here are the size and location of the DNA-binding domain (DBD) from amino acids 539 to 627, the hinge domain from amino acids 628 to 670, and the ligand-binding domain (LBD) from amino acids 671 to 919. Additionally, the polymorphic polyglutamine tract (polyQ) is depicted in the NTD along with the FxxLF motif, which participates in AR intra- and intermolecular amino-carboxyl (N/C) terminal interactions. The nuclear localization signal (NLS) is shown spanning amino acids 617 to 634 in the DBD and hinge regions. Also depicted are the two transactivation domains of the AR: the activation function 1 (AF-1) domain in the NTD and the activation function 2 (AF-2) domain in the LBD