Fig. 7.
Either low or high concentrations of 15d-PGJ2 impair the learning ability of APP/PS1 mice. APP/PS1 mice at the age of 3 months were intranasally treated with 15d-PGJ2 at a concentration of 20 ng/20 μl/day or 1000 ng/20 μl/day for 3 months. The brains were collected after anesthetization. (A) The brains were then stained with an Aβ antibody before analysis by microscopy. (B–E) The learning abilities of different groups of mice were assessed by the Morris water maze test or nest construction assay. *p < 0.05; **p < 0.01; ***p < 0.001 with respect to the APP/PS1 group (n = 6)