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. 2020 Jan 28;9:F1000 Faculty Rev-57. [Version 1] doi: 10.12688/f1000research.21185.1

Figure 1. Unattached or incorrectly attached chromosomes promote formation of the Mitotic Checkpoint Complex (MCC).

Figure 1.

Until bipolar spindle assembly, the MCC, composed of Mad2, BubR1-Bub3, and Cdc20, forms, binds, and blocks APC/C action (SAC ON). Upon bipolar spindle assembly, MCC is dismantled and MCC-free Cdc20 activates APC/C (SAC OFF).