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Reduced production of reactive oxygen species (ROS) in EAE α9/α10 DKO mice. (A) Visualization of ROS was done for wild-type (WT) or nAChR α9/α10 subunit DKO mice (α9−/−α10−/−) by in vivo bioluminescence imaging at day 14 after immunization. (B) Quantification of bioluminescence shows reduced signal intensity in α9−/−α10−/− mice at day 14 after immunization. N = 5 mice per group. Mean ± S.E.M.; unpaired t-test; * p < 0.05.
