Table 2. Relationship between nuclear and membrane CLDN4 expression and clinicopathological parameters.
| Tumor stage/Histopathological grade | n | CLDN4 expression | P | |
|---|---|---|---|---|
| Nuclear | Membrane | |||
| n | 22 | 35 | ||
| G1 | 6 | 6 | 4 | NS |
| G2 | 9 | 9 | 23 | |
| G3 | 7 | 7 | 8 | |
| pStage 1–2 | 14 | 7 | 22 | 0.0307 |
| pStage 3–4 | 8 | 15 | 13 | |
| pT1-2 | 19 | 3 | 21 | 0.0008 |
| pT3-4 | 3 | 19 | 14 | |
| pN0 | 13 | 9 | 25 | 0.029 |
| pN1-2 | 9 | 13 | 10 | |
Tumor stages and histological grades were determined according to the guidelines of Union for International Cancer Control TNM classification system [60].
Abbreviations: NS, not significant.