Table 4:

Observed sequence coverage of 23S rRNA domains following LC-MS analysis

23S rRNA domain	Total Nucleotides	Sequence coverage (%)
		T1	Cus	MC1	Any two RNases#	Total*	MS1 only (with or without MS/MS)
I	541	33	22	28	57	67	88
II	739	19	27	15	43	54	83
III	376	34	26	27	54	64	89
IV	371	36	23	35	58	71	89
V	608	28	29	22	50	60	76
VI	269	27	29	35	52	61	89
Total	2904	28	26	25	48	61	85

^#refers to the sequence coverage reported by at least two of three enzymes

^*refers to the total coverage by all three enzymes