Effects of icv-STZ injection or physiological solution and oral administration of royal jelly or distilled water evaluated in the Elevated Plus Maze Test. (A) %Time - Closed Arm, (B) %Time - Open Arm, (C) %Entries - Open Arm, (D) %Entries - Closed Arm. CTR (n = 7); RJ (n = 8); STZ (n = 8); STZ-RJ (n = 9). CTR = Control; RJ = Royal Jelly; STZ = Streptozotocin; STZ-RJ = Streptozotocin-Royal Jelly. (A) Data expressed as mean ± standard error. For analysis of the data, the analysis of variance (Two-way ANOVA) was used, followed by the Bonferroni post-test. The level of significance was set at p < 0.05.