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. 2009 Sep 1;25(3):132–139. doi: 10.5487/TR.2009.25.3.132

Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats

Yong Soon Kim 14, Min Won Baek 14, Jae Hyuck Sung 14, Hyun Youl Ryu 14, Jin Sik Kim 14, Hyun Sun Cho 14, Byung Gil Choi 14, Min Sub Song 14, Moon Yong Song 14, Eun Ju Baik 14, Young Kuk Choi 14, Jong Kyu Kim 24, Il Je Yu 34, Kyung Seuk Song 14,✉
PMCID: PMC7006341  PMID: 32038831

Abstract

The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 mg/kg body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 mg/kg body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 mg/kg body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.

Key words: Ammonium persulfate, Acute & sub-chronic toxicological test, SD rats, GHS, NOAEL

References

  1. Budavari S. The Merck index: An encyclopedia of chemicals, drugs, and biological. 11th edition. New Jersey: Merck & Co Rahway; 1989. p. 87. [Google Scholar]
  2. FoodDrug Administration FDA . Frequency of use of cosmetic ingredients. FDA database. Washington D.C., USA. 1998. [Google Scholar]
  3. Gamboa PM, de la Cuesta CG, Garcia B E, Castillo J G, Oehling A. Late asthmatic reaction in a hairdresser, due to the inhalation of ammonium persulfate salts. Allegol. Immunopathol. 1999;17:109–111. [PubMed] [Google Scholar]
  4. Huntington Research Center . Ames metabolic activation test to assess the potential mutagenic effect of Ammonium Persulfate. WLA5/77483. (July 14) Washington D.C., USA: Unpublished data submitted by CTFA; 1997. [Google Scholar]
  5. Korean Ministry of Labor . Korean Ministry of Labor Additives codex (Notification No. 2008—11). Examination of toxic risk about industrial chemicals. Korea: Ministry of Labor; 2008. pp. 58–110. [Google Scholar]
  6. Last JA, Dasgupta PK, DeCesare K, Tarkington BK. Inhalation toxicology of ammonium persulfate an oxidant aerosol in rats. Toxicology and Applied Pharmacology. 1982;63:257–263. doi: 10.1016/0041-008X(82)90047-3. [DOI] [PubMed] [Google Scholar]
  7. Matsuzawa T, Inoue H. Biological Reference Data on CD(SD)IGS Rats, CD (SD) IGS Study Group in Charles River Japan, Yokohama, Japan. 2000. [Google Scholar]
  8. Mensing T, Marek W, Raulf HM, Baur X. Acute exposure to hair bleach causes airway hyperre-sponsiveness in a rabbit model. European Respiratory Journal. 1998;12:1371–1374. doi: 10.1183/09031936.98.12061371. [DOI] [PubMed] [Google Scholar]
  9. Merget R, Buenemann A, Kulzer R, Rueckmann A, Breit-stadt R, Kniffka A, Kratisch H, Vormberg R, Schultze-Werninghaus G. A cross sectional study of chemical industry workers with occupational exposure to persulfates. Occup. Environ. Med. 1999;53:422–426. doi: 10.1136/oem.53.6.422. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Nikitakis JM, McEwen GN., Jr. CTFA compendium of cosmetic ingredient composition: Specifications. Washington D.C., USA: Unpublished data submitted by CTFA; 1990. [Google Scholar]
  11. Organization for Economic CooperationDevelopment OECD . Guidelines for the Testing of Chemicals (Sep 21, 1998) TG No. 408 Repeated Dose 90-day Oral Toxicity Study in Rodent. OECD Paris. 1998. [Google Scholar]
  12. Organization for Economic CooperationDevelopment OECD . Guidelines for the Testing of Chemicals (Dec 17, 2001) TG No. 423 Acute Toxic Class Method. OECD Paris. 2001. [Google Scholar]
  13. Registry of Toxic Effects of Chemical Substances RTECS . Ammonium and Potassium Persulfate entries. RTECS database. Bethesda, USA. 1994. [Google Scholar]
  14. Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel JA, Nycum JS. Range-finding toxicity data: List. Am. Ind. Hyg. Assoc. J. 1969;30:470–476. doi: 10.1080/00028896909343157. [DOI] [PubMed] [Google Scholar]
  15. The Cosmetic, Toiletry,Fragrance Association CTFA . Summary of data on Ammonium persulfate. Washington D.C., USA: Unpublished data submitted by CTFA; 1994. [Google Scholar]
  16. United Nation Environment Programme UNEP . Chemical Screening Information Datasheet (SIDS) for High Volume Chemical. New York, USA: UNEP office; 2005. [Google Scholar]
  17. Vanjoost TH, Roesyanto ID. Sensitization to persulphates in occupational and non-occupational hand dermatitis. Contact Dermatitis. 1991;24:376–378. doi: 10.1111/j.1600-0536.1991.tb01760.x. [DOI] [PubMed] [Google Scholar]
  18. Wenninger JA, Canterbery RC, McEwen GN., Jr. International cosmetic ingredient dictionary handbook. 2000;1-2:80. [Google Scholar]

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