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. 2019 Dec 3;159(3):322–334. doi: 10.1111/imm.13151

Figure 3.

Figure 3

Helminth pseudocoelomic fluid (PCF) and butyrate modify gene expression in lipopolysaccharide (LPS) + interferon‐γ (IFN‐γ) ‐stimulated monocyte‐derived dendritic cells (moDCs) differently. (a) Venn diagram displaying unique and shared regulated genes (q value < 0·1) in helminth PCF + LPS + IFN‐γ‐ and butyrate + LPS + IFN‐γ‐stimulated moDCs relative to LPS + IFN‐γ only. (b) Distinct regulation of immune relevant genes in helminth PCF + LPS + IFN‐γ‐ and butyrate + LPS + IFN‐γ‐stimulated moDCs capable of modifying DC‐guided T helper cell polarization and immune cell trafficking. Black: genes down‐regulated by both helminth PCF and butyrate, Black in bold: genes up‐regulated by butyrate, but down‐regulated by PCF, Red: genes down‐regulated by PCF uniquely but not regulated by butyrate. Mo, monocytes; Neu, neutrophils; NK, natural killer cells; Tcyto, cytotoxic T cells; Th1, type 1 T helper cells; Th17, type 17 T helper cells; Th2, type 2 T helper cells; Tregs, regulatory T cells.