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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Hypertension. 2019 Dec 23;75(2):449–457. doi: 10.1161/HYPERTENSIONAHA.119.13822

Figure 2. High salt diet induces more inhibitions in TGF response in vitro and in vivo in female mice than male mice.

Figure 2.

(A-B) TGF response in vivo was indicated by the change of stop flow pressure when the tubular perfusion rate was increased from 0 to 40 nl/min. TGF response in vivo was measured and compared in male and female C57BL/6 mice with normal salt diet or high salt diet. n=10-13 tubules/4-5 mice; *P<0.01 versus normal salt; #P<0.05 versus male mice. (C and D) TGF response in vitro was indicated by the change of Af-Art diameter while the macula densa perfusate was switched from 10 to 80 mM NaCl. TGF response in vitro was measured and compared in male and female C57BL/6 mice with normal salt diet or high salt diet. n=11-12; *P<0.01 versus normal salt; #P<0.05 versus male mice. Statistical difference was calculated by two-way ANOVA followed by Sidak multiple comparisons test.