Extended Data Fig. 8. IV BCG protects against extrapulmonary disease and lung infection across a wide range of thresholds of protection.
a, Extrapulmonary disease was scored at necropsy based on a published system27 taking into account the presence of Mtb-related pathology and Mtb growth from sites outside the thoracic cavity. Each symbol represents an animal and horizontal bars represent the median. Kruskal–Wallis tests were used and reported P values represent Dunn’s multiple comparison test comparing each group to IDlow. All data points within the grey areas are zero. There was no extrapulmonary disease in any of the IV-BCG-vaccinated macaques, whereas the other groups had variable extrapulmonary involvement. b, Fisher’s exact test P values are plotted for a range of CFU thresholds evaluating protection. For each threshold, a stacked bar plot indicates the percentage of NHPs with fewer CFUs than the threshold (that is, protected), in each vaccine group. Immunization route significantly (P < 10−4) impacted protection at any given CFU threshold between <1 (sterile) and <104.