Brief history
A 53-year-old woman with newly diagnosed acute myeloid leukemia (AML) developed a new pruritic, papular eruption approximately 1 week after initiation of induction chemotherapy with daunorubicin and cytarabine. The rash started on her back and progressed to involve the neck, chest, abdomen, and extremities. The patient had persistent neutropenic fevers of unknown etiology and began treatment with cefepime 2 days before the rash developed. She also complained of drenching night sweats. On physical examination, numerous pink edematous papules were scattered across the back, lateral aspects of the neck, chest, abdomen, and extremities (Figs 1 and 2). Punch biopsy of a left thigh lesion was performed (Fig 3).
Fig 1.
Fig 2.
Fig 3.
What is the diagnosis?
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A.
Leukemia cutis
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B.
Transient acantholytic dermatitis
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C.
Neutrophilic eccrine hidradenitis
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D.
Drug-induced hypersensitivity syndrome
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E.
Acute febrile neutrophilic dermatosis
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Footnotes
Funding sources: The authors have no funding sources to declare.
Disclosures: The authors have no conflicts of interest to declare.
IRB approval status: Reviewed and approved by institutional review board.
Informed consent: Informed consent was obtained from the patient for publication of the case.