Table 1.
Cytokine analysis of MSCs and CIMVs-MSCs content.
| Cytokine | MSCs (pg/mL) | CIMVs-MSCs (pg/mL) | p Value |
|---|---|---|---|
| EGF | 141.3 ± 20.6 | 160.7 ± 67.7 | <0.37 |
| FGF-2 | 12114 ± 1433.9 | 10278.5 ± 1020.3 | <0.14 |
| Eotaxin/CCL11 | 48.6 ± 6.2 | 28.9 ± 22.4 | <0.18 |
| * TGF-α | 3 ± 0.1 | 1.6 ± 0.3 | <0.02 |
| G-CSF | 1327.4 ± 457.1 | 1144.3 ± 615 | <0.38 |
| Flt-3L | 19.6 ± 21.4 | 19.3 ± 7.8 | <0.49 |
| GM-CSF | 25.4 ± 6.5 | 15.6 ± 6 | <0.13 |
| Fractalkine/CX3CL | 376.9 ± 28.4 | 548.7 ± 155.8 | <0.07 |
| IFNα2 | 162 ± 43.6 | 83.5 ± 61.7 | <0.14 |
| IFN-γ | 7.5 ± 1.1 | 7.5 ± 3.8 | <0.49 |
| GRO | 661.3 ± 234.1 | 278.6 ± 117.5 | <0.06 |
| IL-10 | 3.3 ± 1.1 | 3.4 ± 0.7 | <0.47 |
| * MCP-3/CCL7 | 60 ± 5 | 37.2 ± 9.3 | <0.05 |
| IL-12p40 | 31.4 ± 12.2 | 27.9 ± 13.4 | <0.40 |
| MDC/CCL22 | 20.7 ± 3.9 | 22.2 ± 6.4 | <0.41 |
| IL-12p70 | 7.4 ± 0.9 | 7 ± 2.9 | <0.42 |
| IL-15 | 18.7 ± 12.5 | 19 ± 5.8 | <0.49 |
| * sCD40L | 9 ± 1.3 | 3.8 ± 2.2 | <0.05 |
| IL-17A | 5.3 ± 0.9 | 2.2 ± 1.5 | <0.06 |
| IL-1RA | 46 ± 35 | 40.6 ± 29 | <0.44 |
| IL-1a | 13.2 ± 1.6 | 10.8 ± 4.8 | <0.29 |
| IL-9 | 136.3 ± 57.1 | 127.6 ± 68.3 | <0.45 |
| * IL-1b | 8.7 ± 0.5 | 4.5 ± 1.1 | <0.02 |
| IL-2 | 9.9 ± 5 | 4 ± 1.9 | <0.13 |
| IL-4 | 18.8 ± 1.6 | 23.7 ± 13.1 | <0.33 |
| IL-5 | 3.8 ± 1.6 | 1.7 ± 0.2 | <0.11 |
| IL-6 | 1833.5 ± 235.4 | 1497.3 ± 513.8 | <0.24 |
| IL-7 | 21 ± 13.3 | 41.3 ± 16.3 | <0.11 |
| IL-8 | 1612.7 ± 487.2 | 721.3 ± 299.2 | <0.08 |
| IP-10 | 108.6 ± 44.9 | 268.1 ± 86.7 | <0.07 |
| MCP-1/CCL2 | 622.4 ± 238.9 | 1164.6 ± 505.1 | <0.09 |
| MIP_1a/CCL3 | 38.7 ± 2.5 | 28.5 ± 5.6 | <0.07 |
| MIP-1b/CCL4 | 82.4 ± 3.7 | 35.4 ± 29.8 | <0.08 |
| TNF-α | 5.1 ± 1.3 | 2 ± 1.1 | <0.06 |
| * TNF-β | 4.8 ± 0.3 | 2.8 ± 0.3 | <0.01 |
| VEGF | 219.8 ± 90 | 215.4 ± 48.1 | <0.48 |
* Cytokines, chemokines, growth factors which are enriched in MSCs compared to CIMVs-MSCs.