Figure 7.

Mutations that cause changes in TRPC6 proteins. A cartoon depicting TRPC6 with its important motifs and mutations (missense substitution, frame shift and deletion). Mutations are presented in bars. Green bars denote GOF mutations, while red bars denote LOF mutations. Gray bars denote mutations with unknown effects (function of which has not been studied), while bars with half green and half red colors denote mutations with controversial effects (controversial reports are found).