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Extracellular vesicles (EVs) from ZIKV-infected mosquito (C6/36) cells participate in the modification of naïve cells’ behavior by mediating cell-to-cell transmission of viral elements (Graphic description). (A) ZIKV C6/36 EVs favor naïve mosquito cell infection. Mosquito image created with BioRender.com. (B) ZIKV C6/36 EVs promote infection and shift to a pro-inflammatory phenotype in monocytes. (C) ZIKV C6/36 EVs participate in the vascular EC infection and activation.
