Skip to main content
. 2019 Dec 4;214(2):409–418. doi: 10.1534/genetics.119.302947

Figure 3.

Figure 3

FSHR-1 functions in a common pathway with SPHK-1 to activate the UPRmt. (A) Left: representative images of Phsp-6::GFP expression in the intestines of wild-type, sphk-1 mutants, fshr-1 mutants, and sphk-1;fshr-1 double mutants in the absence or the presence of PQ for 24 hr. Right: average GFP fluorescence intensity is quantified. (B) Survival rate curves of the indicated strains on plates containing 10 mM PQ. Bar represents 10 µm. One-way ANOVA with Bonferroni post-test: @P < 0.001 compared to sphk-1; &P < 0.001 compared to sphk-1; #P < 0.001 compared to fshr-1; $P < 0.001 compared to fshr-1; and ^P < 0.001 compared to sphk-1;fshr-1; ns: P > 0.05 compared to fshr-1;FSHR-1 neuron rescue; *P < 0.05 compared to wt; and ***P < 0.001 compared to wt. ns, not statistically significant; PQ, paraquat; UPRmt, mitochondrial unfolded protein response; wt, wild-type.