Table 2.
Results from univariable histopathological analysis in KPC tumor tissue for all analyzed parameters. Significance of association with survival was calculated by univariate Cox regression model. Abbreviations: SD, standard deviation; CI, confidence interval; IQR, interquartile range; HR, hazard ratio; MVD, mean vessel density; MLA, mean lumen area; * for continuous variables, HR and 95% CI presented for increase corresponding to IQR.
| Number | Mean ± SD | Median Q1–Q4) | HR (95% CI) | p-Value | |
|---|---|---|---|---|---|
| Ki67 | 44 | 10.6 ± 4.8 | 9.41 (7.05–12.9) | 0.68 (0.43–1.05) * | 0.08 |
| CC3 | 43 | 0.80 ± 0.98 | 0.51 (0.32–0.99) | 0.97 (0.78–1.21) * | 0.79 |
| PHH3 | 45 | 0.41 ± 0.27 | 0.37 (0.22–0.46) | 1.09 (0.82–1.45) * | 0.53 |
| Picrosirius | 46 | 22.1 ± 9.8 | 21.9 (14.3–29.0) | 0.93 (0.59–1.48) * | 0.77 |
| Habp | 46 | 13.2 ± 8.5 | 11.2 (7.72–16.3) | 0.96 (0.70–1.31) * | 0.79 |
| Sparc | 46 | 5.1 ± 2.2 | 4.63 (3.48–6.18) | 0.89 (0.59–1.36) * | 0.61 |
| α–SMA | 46 | 3.4 ± 2.8 | 2.81 (1.72–4.49) | 0.90 (0.63–1.28) * | 0.56 |
| α–SMA+Ki67 | 46 | 6.7 ± 3.4 | 6.27 (4.25–7.79) | 1.27 (0.90–1.79) * | 0.17 |
| MLA (CD31) | 45 | 37.1 ± 11.0 | 34.6 (30.5–46.4) | 0.75 (0.45–1.25) * | 0.27 |
| MVD (CD31) | 45 | 173 ± 64 | 167 (121–219) | 0.98 (0.58–1.66) * | 0.79 |
| Grading (G1 vs. G3) | 46 | - | - | 0.53 (0.25–1.13) | 0.10 |
| Desmoplasia (D1 vs. D2) | 46 | - | - | 1.88 (0.91–3.87) | 0.09 |
| ASI | 46 | 0.23 ± 0.35 | 0.11 (0.06–0.24) | 0.95 (0.82–1.10) * | 0.47 |