Table 5.
Allele and genotype frequencies of fourteen SNPs in RA patients and controls.
| SNPs | Analysis Model | RA n(%) | HC n(%) | χ 2 | OR (95% CI) | padjust Value |
|---|---|---|---|---|---|---|
| rs6790 | Genotype | |||||
| GG | 362 (43.9) | 316 (40.8) | 1.103 | 0.848 (0.623–1.154) | 0.294 | |
| GA | 333 (40.4) | 365 (47.1) | 6.132 | 0.679 (0.499–0.922) | 0.013 | |
| AA | 130 (15.8) | 94 (12.1) | 1.000 | |||
| Allele | ||||||
| G | 1057 (63.9) | 997 (63.4) | 0.024 | 0.989 (0.856–1.142) | 0.877 | |
| A | 593 (36.1) | 553 (36.6) | 1.000 | |||
| Dominant model | ||||||
| AA + GA | 463 (56.1) | 459 (59.2) | 1.630 | 0.878 (0.719–1.072) | 0.202 | |
| GG | 362 (43.9) | 316 (40.8) | 1.000 | |||
| Recessive model | ||||||
| AA | 130 (15.8) | 94 (12.1) | 3.578 | 1.321 (0.990–1.762) | 0.059 | |
| GA + GG | 695 (84.2) | 681 (87.9) | 1.000 | |||
| rs2067051 | Genotypes | |||||
| TT | 101 (12.4) | 80 (10.7) | 1.059 | 1.189 (0.855–1.653) | 0.303 | |
| TC | 335 (41.1) | 306 (41.0) | 0.140 | 1.042 (0.842–1.289) | 0.708 | |
| CC | 380 (46.6) | 360 (48.3) | 1.000 | |||
| Allele | ||||||
| T | 537 (33.0) | 466 (31.6) | 0.998 | 1.080 (0.929–1.255) | 0.318 | |
| C | 1095 (67.0) | 1026 (68.4) | 1.000 | |||
| Dominant model | ||||||
| TT + TC | 436 (53.4) | 386 (51.7) | 0.464 | 1.072 (0.878–1.130) | 0.496 | |
| CC | 380 (46.6) | 360 (48.3) | 1.000 | |||
| Recessive model | ||||||
| TT | 101 (12.4) | 80 (10.7) | 0.923 | 1.167 (0.852–1.598) | 0.337 | |
| TC + CC | 715 (87.6) | 666 (89.3) | 1.000 | |||
| rs2070107 | Genotype | |||||
| GG | 576 (69.2) | 549 (72.0) | 0.022 | 0.955 (0.522–1.747) | 0.881 | |
| GC | 233 (28.0) | 193 (25.3) | 0.089 | 1.100 (0.590–2.050) | 0.765 | |
| CC | 23 (2.8) | 21 (2.8) | ||||
| Allele | ||||||
| G | 1385(83.2) | 1291(84.6) | 1.100 | 0.904 (0.748–1.092) | 0.294 | |
| C | 279 (16.8) | 235 (15.4) | 1.000 | |||
| Dominant model | ||||||
| GC + CC | 256 (30.8) | 214 (28.0) | 1.424 | 1.141 (0.919–1.418) | 0.233 | |
| GG | 576 (69.2) | 549 (72.0) | 1.000 | |||
| Recessive model | ||||||
| CC | 23 (2.8) | 21 (2.8) | 0.001 | 1.008(0.553–1.838) | 0.980 | |
| GC + GG | 809 (97.2) | 742 (97.2) | ||||
| rs2075745 | Genotype | |||||
| TT | 113 (14.1) | 106 (14.2) | 0.080 | 0.956 (0.703–1.302) | 0.777 | |
| TA | 340 (42.3) | 318 (42.6) | 0.026 | 0.982 (0.791–1.219) | 0.871 | |
| AA | 350 (43.6) | 323 (43.2) | 1.000 | |||
| Allele | ||||||
| T | 566 (35.2) | 530 (35.5) | 0.018 | 0.990 (0.854–1.147) | 0.892 | |
| A | 1040 (64.8) | 964 (64.5) | 1.000 | |||
| Dominant model | ||||||
| TT + TA | 453 (56.4) | 424 (56.8) | 0.056 | 0.976 (0.797–1.194) | 0.812 | |
| AA | 350 (43.6) | 323 (43.2) | 1.000 | |||
| Recessive model | ||||||
| TT | 113 (14.1) | 106 (14.2) | 0.058 | 0.965(0.722–1.289) | 0.809 | |
| TA + AA | 690 (85.9) | 641 (85.8) | 1.000 | |||
| rs2285991 | Genotype | |||||
| GG | 678 (86.1) | 612 (86.6) | 0.773 | 0.611 (0.203–1.834) | 0.379 | |
| GA | 100 (12.7) | 90 (12.7) | 0.719 | 0.613 (0.198–1.900) | 0.396 | |
| AA | 9 (1.1) | 5 (0.7) | 1.000 | |||
| Allele | ||||||
| G | 1456 (92.5) | 1314 (92.9) | 0.199 | 0.939 (0.712–1.238) | 0.656 | |
| A | 118 (7.5) | 100 (7.1) | 1.000 | |||
| Dominant model | ||||||
| GA + AA | 109 (13.9) | 95 (13.4) | 0.058 | 1.037 (0.770–1.397) | 0.809 | |
| GG | 678 (86.1) | 612 (86.6) | 1.000 | |||
| Recessive model | ||||||
| AA | 9 (1.1) | 5 (0.7) | 0.772 | 1.637 (0.545–4.914) | 0.380 | |
| GA + GG | 778 (98.9) | 702 (99.3) | 1.000 | |||
| rs2632516 | Genotype | |||||
| GG | 270 (32.6) | 229 (29.4) | 1.151 | 1.161 (0.884–1.527) | 0.283 | |
| GC | 379 (45.8)) | 373 (47.8) | 0.015 | 1.016 (0.789–1.309) | 0.901 | |
| CC | 179 (21.6) | 178 (22.8) | 1.000 | |||
| Allele | ||||||
| G | 919 (55.5) | 831 (53.3) | 1.604 | 1.094 (0.952–1.257) | 0.205 | |
| C | 737 (44.5) | 729 (46.7) | 1.000 | |||
| Dominant model | ||||||
| GG + GC | 649 (78.4) | 602 (77.2) | 0.329 | 1.072 (0.846–1.357) | 0.566 | |
| CC | 179 (21.6) | 178 (22.8) | 1.000 | |||
| Recessive model | ||||||
| GG | 270 (32.6) | 229 (29.4) | 1.632 | 1.149 (0.928–1.422) | 0.201 | |
| GC + CC | 558 (67.4) | 551 (70.6) | 1.000 | |||
| rs2877877 | Genotype | |||||
| GG | 50 (6.1) | 53 (7.3) | 1.270 | 0.790 (0.524–1.190) | 0.260 | |
| GA | 272 (33.1) | 248 (34.3) | 0.561 | 0.921 (0.741–1.143) | 0.454 | |
| AA | 500 (60.8) | 422 (58.4) | 1.000 | |||
| Allele | ||||||
| G | 372 (22.6) | 354 (24.5) | 1.470 | 0.902 (0.764–1.066) | 0.225 | |
| A | 1272 (77.4) | 1092 (75.5) | 1.000 | |||
| Dominant model | ||||||
| GG + GA | 322 (39.2) | 301 (41.6) | 1.070 | 0.898 (0.731–1.101) | 0.301 | |
| AA | 500 (60.8) | 422 (58.4) | 1.000 | |||
| Recessive model | ||||||
| GG | 50 (6.1) | 53 (7.3) | 1.006 | 0.814 (0.544–1.217) | 0.316 | |
| GA + AA | 772 (93.9) | 670 (92.7) | 1.000 | |||
| rs13414 | Genotype | |||||
| AA | 368 (51.0) | 316 (46.7) | 0.149 | 1.076 (0.741–1.563) | 0.700 | |
| AG | 283 (39.3) | 295 (43.6) | 0.403 | 0.885 (0.606–1.292) | 0.526 | |
| GG | 70 (9.7) | 65 (9.6) | 1.000 | |||
| Allele | ||||||
| A | 1019 (70.7) | 927 (68.6) | 1.456 | 1.104 (0.940–1.298) | 0.228 | |
| G | 423 (29.3) | 425 (31.4) | 1.000 | |||
| Dominant model | ||||||
| AG + GG | 353 (49.0) | 360 (53.3) | 2.551 | 0.841 (0.681–1.040) | 0.110 | |
| AA | 368 (51.0) | 316 (46.7) | 1.000 | |||
| Recessive model | ||||||
| GG | 70 (9.7) | 65 (9.6) | 0.008 | 1.016 (0.710–1.455) | 0.930 | |
| AG + AA | 651 (90.3) | 611 (90.4) | 1.000 | |||
| rs4372750 | Genotype | |||||
| AA | 168 (23.5) | 156 (23.0) | 0.184 | 1.070 (0.786–1.456) | 0.668 | |
| AC | 378 (52.8) | 352 (51.9) | 0.370 | 1.084 (0.836–1.405) | 0.543 | |
| CC | 170 (23.7) | 170 (25.1) | 1.000 | |||
| Allele | ||||||
| A | 714 (49.9) | 664 (49.0) | 0.222 | 1.036 (0.893–1.202) | 0.637 | |
| C | 718 (50.1) | 692 (51.0) | 1.000 | |||
| Dominant model | ||||||
| AA + AC | 546 (76.3) | 508 (74.9) | 0.318 | 1.074 (0.839–1.374) | 0.573 | |
| CC | 170 (23.7) | 170 (25.1) | 1.000 | |||
| Recessive model | ||||||
| AA | 168 (23.5) | 156 (23.0) | 0.006 | 1.007 (0.999–1.015) | 0.937 | |
| AC+CC | 548 (76.5) | 522 (77.0) | 1.000 | |||
| rs12601867 | Genotype | |||||
| CC | 165 (22.6) | 166 (24.0) | 0.953 | 0.860 (0.634–1.165) | 0.329 | |
| CG | 381 (52.1) | 361 (52.2) | 0.274 | 0.934 (0.723–1.206) | 0.601 | |
| GG | 185 (25.3) | 165 (23.8) | 1.000 | |||
| Allele | ||||||
| C | 711 (48.6) | 693 (50.1) | 0.590 | 0.944 (0.815–1.094) | 0.442 | |
| G | 751 (51.4) | 691 (49.9) | 1.000 | |||
| Dominant model | ||||||
| CG + GG | 566 (77.4) | 526 (76.0) | 0.681 | 1.111 (0.866–1.425) | 0.409 | |
| CC | 165 (22.6) | 166 (24.0) | 1.000 | |||
| Recessive model | ||||||
| GG | 185 (25.3) | 165 (23.8) | 0.571 | 1.098 (0.861–1.400) | 0.450 | |
| CG + CC | 546 (74.7) | 527 (76.2) | 1.000 | |||
| rs16847206 | Genotype | |||||
| AA | 338 (46.5) | 296 (43.7) | 1.358 | 1.247 (0.860–1.808) | 0.244 | |
| AT | 325 (44.7) | 308 (45.5) | 0.679 | 1.169 (0.806–1.694) | 0.410 | |
| TT | 64 (8.8) | 73 (10.8) | 1.000 | |||
| Allele | ||||||
| A | 1001 (68.8) | 900 (66.5) | 1.808 | 1.115 (0.952–1.306) | 0.179 | |
| T | 453 (31.2) | 454 (33.5) | 1.000 | |||
| Dominant model | ||||||
| AT + TT | 389 (53.5) | 381 (56.3) | 0.735 | 0.911 (0.737–1.127) | 0.391 | |
| AA | 338 (46.5) | 296 (43.7) | 1.000 | |||
| Recessive model | ||||||
| TT | 64 (8.8) | 73 (10.8) | 1.086 | 0.828 (0.581–1.180) | 0.297 | |
| AT + AA | 663 (91.2) | 604 (89.2) | ||||
| rs6692753 | Genotype | |||||
| GG | 339 (46.6) | 287 (42.0) | 1.624 | 1.272 (0.878–1.843) | 0.203 | |
| GT | 323 (44.4) | 323 (47.3) | 0.241 | 1.097 (0.758–1.587) | 0.623 | |
| TT | 65 (8.9) | 73 (10.7) | 1.000 | |||
| Allele | ||||||
| G | 1001 (68.8) | 897 (65.7) | 3.231 | 1.155 (0.987–1.352) | 0.072 | |
| T | 453 (31.2) | 469 (34.3) | 1.000 | |||
| Dominant model | ||||||
| GT + TT | 388 (53.4) | 396 (58.0) | 2.315 | 0.848 (0.686–1.049) | 0.128 | |
| GG | 339 (46.6) | 287 (42.0) | 1.000 | |||
| Recessive model | ||||||
| TT | 65 (8.9) | 73 (10.7) | 0.842 | 0.848 (0.596–1.206) | 0.359 | |
| GT + GG | 662 (91.1) | 610 (89.3) | 1.000 | |||
| rs2680700 | Genotype | |||||
| GG | 412 (57.3) | 376 (55.1) | 1.773 | 0.755 (0.499–1.142) | 0.183 | |
| GT | 243 (33.8) | 263 (38.6) | 4.477 | 0.630 (0.411–0.967) | 0.034 | |
| TT | 64 (8.9) | 43 (6.3) | 1.000 | |||
| Allele | ||||||
| G | 1067 (74.2) | 1015 (74.4) | 0.017 | 0.989 (0.835–1.172) | 0.897 | |
| T | 371 (25.8) | 349 (25.6) | 1.000 | |||
| Dominant model | ||||||
| GT + TT | 307 (42.7) | 306 (44.9) | 0.857 | 0.904 (0.731–1.119) | 0.355 | |
| GG | 412 (57.3) | 376 (55.1) | 1.000 | |||
| Recessive model | ||||||
| TT | 64 (8.9) | 43 (6.3) | 2.896 | 1.421 (0.948–2.131) | 0.089 | |
| GT+GG | 655 (91.1) | 639 (93.7) | 1.000 | |||
| rs8071916 | Genotype | |||||
| AA | 175 (24.1) | 162 (23.4) | 0.016 | 1.020 (0.751–1.384) | 0.900 | |
| AG | 378 (52.0) | 366 (53.0) | 0.015 | 0.984 (0.758–1.277) | 0.904 | |
| GG | 174 (23.9) | 163 (23.6) | 1.000 | |||
| Allele | ||||||
| A | 728 (50.1) | 690 (49.9) | 0.006 | 1.006 (0.868–1.165) | 0.940 | |
| G | 726 (49.9) | 692 (50.1) | 1.000 | |||
| Dominant model | ||||||
| AG + GG | 552 (75.9) | 529 (76.6) | 0.059 | 0.970 (0.758–1.241) | 0.808 | |
| AA | 175 (24.1) | 162 (23.4) | 1.000 | |||
| Recessive model | ||||||
| GG | 174 (23.9) | 163 (23.6) | 0.002 | 1.005 (0.785–1.287) | 0.969 | |
| AG + AA | 553 (76.1) | 528 (76.4) | 1.000 | |||
RA, rheumatoid arthritis; HC, control; OR, odds ratio; CI, confidence interval; SNPs, single nucleotide polymorphisms; padjust, p value adjusted for gender and age.