Table 1.
Selected examples of polysaccharides-based colonic delivery system.
| Polysaccharide | Delivery System | API | Mechanism | Ref |
|---|---|---|---|---|
| Alginate | Calcium alginate beads coated with Eudragit® S-100 | Curcumin | pH responsive, enzyme sensitive, and mucoadhesiveness | [64] |
| Alginate | Calcium alginate-Carboxymethyl cellulose beads | 5-fluorouracil | pH responsive, enzyme sensitive, and mucoadhesiveness | [65] |
| Alginate/Chitosan | Chitosan succinate-Sodium alginate beads | Capecitabine | pH responsive, enzyme sensitive, and mucoadhesiveness | [66] |
| Alginate/Portulaca | Portulaca-Sodium alginate/Borax composite microbeads | 5-fluorouracil | pH responsive, enzyme sensitive, and mucoadhesiveness | [67] |
| Alginate/Chitosan/Konjac glucomannan | Chitosan coated konjac glucomannan/Sodium alginate/Graphene oxide microspheres | Ciprofloxacin | pH responsive, enzyme sensitive, and mucoadhesiveness | [68] |
| Alginate/Pectin | Sodium alginate liposome coated with pectin | Salmon calcitonin | pH responsive, enzyme sensitive, and mucoadhesiveness | [69] |
| Alginate/Chitosan | Alginate/Chitosan microcapsules | Interleukin-1Ra | pH responsive, enzyme sensitive, and mucoadhesiveness | [70] |
| Alginate/Chitosan/Kappa- carrageenan | Dual layered pH-sensitive Alginate/Chitosan/Kappa- carrageenan microbeads | 5-Flurouracil | pH responsive, enzyme sensitive, and mucoadhesiveness | [71] |
| Pectin/Chitosan | Pectin/Chitosan beads containing drug loaded in potato starch | Doxorubicin | Enzyme sensitive and mucoadhesiveness | [58] |
| Pectin/Chitosan | Modified citrus pectinate-chitosan nanoparticle (MCPCNP) | Curcumin | Enzyme sensitive and mucoadhesiveness | [72] |
| Pectin/Chitosan | Modified citrus pectinate-chitosan nanoparticle (MCPCNP) | Cetuximab Curcumin |
Enzyme sensitive and mucoadhesiveness | [73] |
| Pectin/Chitosan | Chitosan-Zinc-Pectinate-Polyethylene glycol (PEG) nanoparticles (NPs) | Resveratrol | Enzyme sensitive and mucoadhesiveness | [74] |
| Chitosan/Nutriose | PEG-containing vesicles coated with chitosan/nutriose | Quercetin | Enzyme sensitive and mucoadhesiveness | [75] |
| Pectin | Pectin-Zinc acetate beads coated with Eudragit S100 | Pterostilbene | pH responsive and enzyme sensitive | [76] |
| Pectin | Pectin/Polyethylene glycol hydrogel system containing in-situ mineralized calcium carbonate microparticle | Bovine serum albumin | Enzyme sensitive and mucoadhesiveness | [77] |
| Guar Gum | Guar Gum capped mesoporous silica nanoparticles | 5-Flurouracil | Enzyme sensitive and Nanoparticle | [78] |
| Guar Gum | Ethylene glycol dimethacrylate cross-linked guar gum oleate-graft-poly (methacrylic acid) hydrogel | Ibuprofen | pH responsive, enzyme sensitive, and mucoadhesiveness | [79] |
| Inulin | Cinnamate inulin microsphere hydrogel system | Methotrexate | Enzyme sensitive and mucoadhesiveness | [80] |