Table 2.

Studies (2009–2019) that evaluate proteins and processes involved in the immune response of the animal models or cell line host after Aeromonas spp. (adapted from [20]).

Proteins or Process Studied	Host	Aeromonas sp.	Reference
Toll-like receptors (TLRs) (TLR1, TLR2, TLR3, TLR4, TLR5, TLR7, TLR8, TLR9, TLR18, TLR19, TLR20, TLR22)	Fish, cells (EPC, HKLs, Hep-2)	A. hydrophila, A. salmonicida, A. veronii	[21,24,282,283,286,287,288,289,290,291,292]
Cytokines (TNF-α, TNF- β, IFN-γ, IL-6, IL-8, IL-10)	Fish, mice, cells (Hep-2, HKLs, RAW 264.7, HeLa)	A. hydrophila, A. salmonicida, A. dhakensis, A. veronii/A. hydrophila	[259,289,290,293,294,295,296]
Chemokines (CC-Chem14, CsCC-Chem20, CsCC-Chem25, CCL3, CCL5)	Fish, mice, cells (HeLa, RAW 264.7)	A. hydrophila, A. dhakensis	[259,295,297,298]
Transcription factors (JUN, RELA)	Fish, cells (Caco-2)	A. hydrophila, A. salmonicida, A. veronii, A. bestiarum, A. allosaccharophila	[299,300]
Apoptosis (TP53, CASP3)	Fish, mice, cells (HeLa, RAW 264.7, macrophages from fish, SLs, HKLs)	A. hydrophila, A. veronii	[295,301,302,303,304,305]
Pyroptosis (NLRP3, NLRC4, IL-1β)	Mice, macrophages from mice	A. hydrophila, A. veronii	[22,23]

Epithelioma papulosum cyprini cell line (EPC); head kidney leukocytes (HKLs), human epithelial cell line (Hep-2); murine macrophage cell line (RAW 264.7); human epithelial type cell line (HeLa); human epithelial colorectal adenocarcinoma cell line (Caco-2); spleen leukocytes (SLs). The strains of these studies [282,283,286,292,293,294,296,297,302] were identified by non-molecular methods or lack information about the identification.