Figure 5.

Number of the writhes of acetic acid treated rats after sustained-release TTX pellets treatment. Saline, TTX formulation or ibuprofen was intragastrically (i.g.) administrated at 0 h. Then, 0.6% acetic acid solution (10 ml/kg, intraperitoneally) was administrated at different time points (1.5 h, 3 h, 6 h, 9 h, 12 h, 18 h and 24 h). At each time point, the number of writhing during a 30-min duration following acetic acid solution injection was counted and recorded. Data are expressed as mean ± SD (n = 10). * p < 0.05, ** p < 0.01 and *** p < 0.001 compared with control.