Table 1.
Significantly altered (FDR < 0.05) metabolites in S. enterica ridA background.
| 1 Compound | 2 Mean (SD) | 3 Fold Change | p Value | FDR Value | |
|---|---|---|---|---|---|
| Wild-Type | ridA | ||||
| Valine | 1.23 (0.13) | 2.71 (0.13) | 2.20 | 8.47 × 10−14 | 3.56× 10−12 |
| Methionine | 0.08 (0.01) | 0.17 (0.01) | 2.20 | 4.43 × 10−12 | 9.31× 10−11 |
| GSSG | 0.54 (0.20) | 2.02 (0.18) | 3.71 | 1.99× 10−11 | 2.78× 10−10 |
| CMP | 0.05 (0.02) | 0.13 (0.02) | 2.94 | 1.38 × 10−8 | 8.29 × 10−8 |
| 2-isopropylmalic acid | 0.32 (0.04) | 1.30 (0.45) | 4.03 | 7.54× 10−6 | 3.52 × 10−5 |
| Glucose | 0.04 (0.01) | 0.06 (0.01) | 1.40 | 1.41 × 10−5 | 5.37 × 10−5 |
| Maltose | 1.41 (0.11) | 1.60 (0.10) | 1.13 | 2.13 × 10−3 | 5.17 × 10−3 |
| UTP | 0.04 (0.01) | 0.06 (0.01) | 1.43 | 8.79 × 10−3 | 0.02 |
| Glutamate | 0.18 (0.04) | 0.25 (0.06) | 1.41 | 9.82 × 10−3 | 0.02 |
| Threonine | 0.05 (0.01) | 0.06 (0.01) | 1.22 | 0.02 | 0.03 |
| Pantothenic acid | 0.13 (0.02) | 0.16 (0.02) | 1.17 | 0.03 | 0.04 |
| Leucine | 1.90 (0.25) | 0.80 (0.06) | 0.42 | 6.61 × 10−10 | 6.94 × 10−9 |
| Lysine | 0.59 (0.13) | 0.07 (0.02) | 0.12 | 1.53 × 10−9 | 1.29 × 10−8 |
| Phenylalanine | 0.13 (0.03) | 0.02 (0.01) | 0.12 | 1.38 × 10−8 | 8.29 × 10−8 |
| dCMP | 0.68 (0.08) | 0.44 (0.03) | 0.65 | 4.88 × 10−7 | 2.56 × 10−6 |
| Succinic acid | 2.49 (0.35) | 1.67 (0.20) | 0.67 | 1.39 × 10−5 | 5.37 × 10−5 |
| AMP | 0.70 (0.14) | 0.42 (0.05) | 0.60 | 2.92 × 10−5 | 1.02 × 10−4 |
| NADP | 0.05 (0.01) | 0.04 (0.01) | 0.74 | 9.71 × 10−5 | 3.14 × 10−4 |
| Formate | 0.16 (0.02) | 0.12 (0.02) | 0.76 | 2.79 × 10−4 | 8.38 × 10−4 |
| N-acetylputrescine | 0.16 (0.02) | 0.12 (0.02) | 0.77 | 1.11 × 10−3 | 3.10 × 10−3 |
| Isoleucine | 0.37 (0.12) | 0.22 (0.02) | 0.61 | 1.89 × 10−3 | 4.95 × 10−3 |
| Acetate | 2.50 (0.26) | 2.12 (0.18) | 0.85 | 2.22 × 10−3 | 5.17 × 10−3 |
| Serine | 0.06 (0.01) | 0.05 (0.01) | 0.87 | 0.01 | 0.03 |
1 Abbreviations: GSSG: glutathione disulfide, CMP: cytidine monophosphate, UTP: uridine triphosphate, dCMP: deoxycytidine monophosphate, AMP: adenosine monophosphate, NADP: nicotinamide adenine dinucleotide phosphate, CDP: cytidine diphosphate, NMN: nicotinate mononucleotide, UMP: uridine monophosphate, CTP: cytidine triphosphate, NAD: nicotinamide adenine dinucleotide. 2 Values reflect the relative mean area and standard deviation (SD) for the feature assigned to the corresponding metabolite. 3 Fold-change provided as ridA/wild-type.