Table 2. Univariate analysis of prognostic factors influencing disease free survival (DFS) and overall survival (OS) in stage I–III colorectal cancer.
| Characteristics | DFS | P | OS | P |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| Gender | ||||
| Male vs female | 1.13 [0.71–1.83] | 0.6 | 1.18 [0.7–2.0] | 0.54 |
| Age (year) | ||||
| ≤50 vs >50 | 0.49 [0.25–0.97] | 0.04 | 0.47 [0.22–0.97] | 0.04 |
| Location | ||||
| Right side colon vs left side colon vs rectum | 0.73 | 0.85 | ||
| Mucin production | ||||
| With vs without | 1.75 [0.89–3.47] | 0.11 | 1.8 [0.85–3.80] | 0.12 |
| Tumor differentiation | ||||
| Poor vs moderate/well | 2.56 [1.40–4.68] | 0.002 | 2.08 [1.09–3.99] | 0.03 |
| Tumor stage | ||||
| I vs II vs III | 0.06 | 0.001 | ||
| Bowel wall invasion (T) | ||||
| T1+T2 vs T3+T4 | 0.54 [0.30–0.97] | 0.04 | 0.44 [0.23–0.85] | 0.01 |
| Tumor diameter | ||||
| ≤5 cm vs >5 cm | 1.17 [0.73–1.88] | 0.5 | 1.11 [0.66–1.86] | 0.7 |
| Lymph node metastasis (N) | ||||
| Without vs with | 0.59 [0.36–0.95] | 0.03 | 0.39 [0.23–0.66] | 0.001 |
| Lymphovascular invasion | ||||
| No vs yes | 0.41 [0.24–0.69] | 0.001 | 0.42 [0.23–0.75] | 0.001 |
| Alcohol intake | ||||
| Ever vs never | 1.1 [0.62–1.94] | 0.75 | 0.97 [0.52–1.81] | 0.91 |
| Smoking | ||||
| Ever vs never | 1.3 [0.77–2.19] | 0.32 | 0.99 [0.55–1.77] | 0.97 |
| Cancer family history | ||||
| Yes vs no | 1.86 [0.92–3.76] | 0.09 | 1.91 [0.86–4.28] | 0.11 |
| Colorectal family history | ||||
| Yes vs no | 1.12 [0.41–3.06] | 0.83 | 0.75 [0.23–2.44] | 0.64 |
| MSI status | ||||
| MSI vs MSS | 1.14 [0.58–2.25] | 0.69 | 0.98 [0.46–2.06] | 0.95 |
| RAS status | ||||
| RAS mutation vs RAS wildtype | 1.35 [0.84–2.19] | 0.21 | 1.45 [0.86–2.25] | 0.16 |
| BRAF status | ||||
| BRAF mutation vs BRAF wildtype | 3.41 [0.91–12.74] | 0.07 | 1.08 [0.25–4.68] | 0.92 |
| HER2 status | ||||
| HER2 amplification vs HER2 negative | 3.97 [1.35–11.72] | 0.007 | 2.98 [0.92–9.67] | 0.08 |