Figure 2.

Occurrence of interaction types at the nACE and cACE binding interfaces from IFPs for ACE-ligand structures reported in PDB, (nACE-ligand structures are in (A) and cACE-ligand structures are in (B)). Top part of both A and B plots % of occurrence of contacts C, interactions with the backbone of the residue B, and interactions with the side chain of the residue S per residue. Bottom part of both A and B plots % of occurrence of chemical interactions: contacts C, polar P, hydrophobic H, HBs where the residue is acceptor A, HBs where the residue is donor D, aromatic Ar, and electrostatic with charged groups Ch.