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. 2020 Jan 10;25(2):291. doi: 10.3390/molecules25020291

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Evidences supporting the role of Macrophage Migration Inhibitory Factor (MIF) in Alzheimer′s disease (AD). In-vitro, in-vivo, and ex-vivo preclinical data, as well as data from AD and MCI patients show that MIF is increased during the course of the disease and that therapeutic intervention aimed at counteracting MIF function may exert beneficial effects on AD course. MCI: Mild Cognitive Impairment; Ab: Amyloid Beta; APP: Amyloid Precursor Protein; PS1: Presenilin 1; CSF: CerebroSpinal fluid; KO: Knockout; ISO-1: 4,5-Dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid methyl ester.